Trial reportThe Journal of allergy and clinical immunology2010
Predictors of remitting, periodic, and persistent childhood asthma.
Trial report in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 107 citations in OpenAlex.
- Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications.The Journal of allergy and clinical immunology · 2014Trial
- Remission in moderate-to-severe pediatric asthma: Definitions, assessment, prevalence, predictors, and outcomes-a scoping review.The journal of allergy and clinical immunology. Global · 2026Article
- Is Asthma Remission a New Achievable Goal? A Review of the Current Drug-Related Evidence and Predictors.Allergy · 2026Review
- The definition of asthma remission in children: A scoping review by the WAO Paediatric Asthma Committee.The World Allergy Organization journal · 2026Review
- The Role of Environmental Exposures in Pediatric Asthma Pathogenesis: A Contemporary Narrative Review.Children (Basel, Switzerland) · 2025Review
- Associations between in-home environmental exposures and lung function in a safety net population of children with asthma using electronic health records and geospatial data.Annals of epidemiology · 2025Article
- Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study.Allergy, asthma & immunology research · 2025Article
- Relationship between early life asthma and chronic airway disease in adult life - in search for disease trajectories over the life span- the RELATE study based on the Kongsberg cohort.BMC pulmonary medicine · 2023Observational
- Review
- Severe asthma in children: An official statement from Saudi Pediatric Pulmonology Association.Saudi medical journal · 2022Article
- Factors associated with resolution of childhood asthma by the age of 17: Large cohort analysis.Pediatric pulmonology · 2022Article
- Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management.Nutrients · 2021Review
- Ongoing asthma management in children during the COVID-19 pandemic: to step down or not to step down?The Lancet. Respiratory medicine · 2021Article
- Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?Physiological reviews · 2020Review
- Remission of persistent childhood asthma: Early predictors of adult outcomes.The Journal of allergy and clinical immunology · 2019Article
- Can early intervention in pediatric asthma improve long-term outcomes? A question that needs an answer.Pediatric pulmonology · 2019Review
- Omalizumab and unmet needs in severe asthma and allergic comorbidities in Japanese children.Asia Pacific allergy · 2019Review
- Modeling asynchronous event sequences with RNNs.Journal of biomedical informatics · 2018Article
- Ascertainment of asthma prognosis using natural language processing from electronic medical records.The Journal of allergy and clinical immunology · 2018Article
- Maturation of the gut microbiome and risk of asthma in childhood.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe course of mild to moderate persistent asthma in children is not clearly established.
objectiveTo determine the rate and predictors for remitting, periodic, and persistent asthma in adolescence.
methodsThe Childhood Asthma Management Program (CAMP) was a 4.3-year randomized, double-masked, multicenter trial in children with mild to moderate persistent asthma that compared continuous therapy with either budesonide or nedocromil, each to placebo, followed by a 4-year observational follow-up period. Asthma activity during the observation period included remitting (no asthma activity in the last year), persistent (asthma activity in every quarter), and periodic asthma (neither remitting nor persistent).
resultsAsthma was identified as remitting in 6%, periodic in 39%, and persistent in 55% of the 909 participants, with no effect noted from earlier anti-inflammatory treatment during the CAMP trial. Within all 3 asthma activity categories, improvements in airway hyperresponsiveness, eosinophilia, and asthma morbidity were observed over time. Features at entry into CAMP associated with remitting versus persistent asthma were lack of allergen sensitization and exposure to indoor allergens (odds ratio [OR], 3.23; P < .001), milder asthma (OR, 2.01; P = .03), older age (OR, 1.23; P = .01), less airway hyperresponsiveness (higher log methacholine FEV(1) PC(20) (OR, 1.39; P = .03), higher prebronchodilator FEV(1) percent predicted (OR, 1.05; P = .02), and lower forced vital capacity percent predicted (OR, 0.96; P = .04).
conclusionRemission of asthma in adolescence is infrequent and not affected by 4 years of anti-inflammatory controller therapy. Factors such as sensitization and exposure, low lung function, and airway greater hyperresponsiveness decrease the likelihood of remitting asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.