ArticleBiophysical journal2010
Drag force as a tool to test the active mechanical response of PC12 neurites.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Actin Stress Fibers Response and Adaptation under Stretch.International journal of molecular sciences · 2022Article
- Magnetically-actuated microposts stimulate axon growth.Biophysical journal · 2022Article
- Cytoskeletal Mechanisms of Axonal Contractility.Biophysical journal · 2018Article
- Non-invasive Neurite Mechanics in Differentiated PC12 Cells.Frontiers in cellular neuroscience · 2018Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- Mechanism of Axonal Contractility in Embryonic Drosophila Motor Neurons In Vivo.Biophysical journal · 2016Article
- Traction force and tension fluctuations in growing axons.Frontiers in cellular neuroscience · 2015Article
- Dynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons.Scientific reports · 2014Article
- Growth cones as soft and weak force generators.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mechanical manipulation of neurons to control axonal development.Journal of visualized experiments : JoVE · 2011Article
- The role of the cytoskeleton in volume regulation and beading transitions in PC12 neurites.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the mechanical response of PC12 neurites subjected to a drag force imposed by a laminar flow perpendicular to the neurite axis. The curvature of the catenary shape acquired by an initially straight neurite under the action of the drag force provides information on both elongation and tension of the neurite. This method allows us to measure the rest tension and viscoelastic parameters of PC12 neurites and active behavior of neurites. Measurement of oscillations in the strain rate of neurites at constant flow rate provides insight on the response of molecular motors and additional support for the presence of a negative strain-rate sensitivity region in the global mechanical response of PC12 neurites.
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Registered trials
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