ArticleCellular signalling2010
Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan.
Article in Cellular signalling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction.Function (Oxford, England) · 2026Article
- Epicardium-myocardium crosstalk orchestrates heart development.Frontiers in cell and developmental biology · 2025Review
- CCBE1 Is Essential for Epicardial Function during Myocardium Development.International journal of molecular sciences · 2022Article
- Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials.Frontiers in bioengineering and biotechnology · 2021Review
- What Can be Learned from the Time Course of Changes in Low-Frequency Stimulated Muscle?European journal of translational myology · 2017Article
- More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.Frontiers in cell and developmental biology · 2017Review
- Article
- Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.Biomaterials · 2015Article
- Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility.Cellular signalling · 2015Article
- Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells.Biomaterials · 2014Article
- The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart.Journal of developmental biology · 2014Article
- Local activation of cardiac stem cells for post-myocardial infarction cardiac repair.Journal of cellular and molecular medicine · 2012Review
- TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway.Cellular signalling · 2012Article
- Hyaluronan regulates cell behavior: a potential niche matrix for stem cells.Biochemistry research international · 2012Article
- The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.Developmental biology · 2011Article
- Extracellular matrix and heart development.Birth defects research. Part A, Clinical and molecular teratology · 2011Review
- TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.Experimental cell research · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During embryonic development, cells comprising the outermost layer of the heart or epicardium play a critical role in the formation of the coronary vasculature. Thus, uncovering the molecular mechanisms that govern epicardial cell behavior is imperative to better understand the etiology of cardiovascular diseases. In this study, we investigated the function of hyaluronan (HA), a major component of the extracellular matrix, in the modulation of epicardial signaling. We show that stimulation of epicardial cells with high molecular weight HA (HMW-HA) promotes the association of MEKK1 with the HA receptor CD44 and induces MEKK1 phosphorylation. This leads to the activation of two distinct pathways, one ERK-dependent and another NFkappaB-dependent. Furthermore, HMW-HA stimulates epicardial cells to differentiate and invade, as suggested by increased vimentin expression and enhanced invasion through a collagen matrix. Blockade of CD44, transfection with a kinase-inactive MEKK1 construct or the use of ERK1/2 and NFkappaB inhibitors significantly abrogates the invasive response to HMW-HA. Together, these findings suggest an important role for HA in the regulation of epicardial cell fate via activation of MEKK1 signaling cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.