ArticleComparative medicine2010
Perturbations in cytokine gene expression after inoculation of C57BL/6 mice with Pasteurella pneumotropica.
Article in Comparative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Evaluation of the Efficacy of Disinfectants in Reducing Contamination of Bacterial and Viral Murine Pathogens on Gloved Hands.Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Health Monitoring of Laboratory Rodent Colonies-Talking about (R)evolution.Animals : an open access journal from MDPI · 2021Review
- Current Distribution ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- The Likelihood of Misidentifying Rodent Pasteurellaceae by Using Results from a Single PCR Assay.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Article
- Exhaust Air Dust Monitoring is Superior to Soiled Bedding Sentinels for the Detection of Pasteurella pneumotropica in Individually Ventilated Cage Systems.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- High-Resolution Melting Curve Analysis for Identification of Pasteurellaceae Species in Experimental Animal Facilities.PloS one · 2015Article
- Characterization of Biofilm Formation in [Pasteurella] pneumotropica and [Actinobacillus] muris Isolates of Mouse Origin.PloS one · 2015Article
- Elimination of Pasteurella pneumotropica from a mouse barrier facility by using a modified enrofloxacin treatment regimen.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Draft Genome Sequence of the Rodent Opportunistic Pathogen Pasteurella pneumotropica ATCC 35149T.Genome announcements · 2014Article
- Environmentally determined differences in the murine lung microbiota and their relation to alveolar architecture.PloS one · 2014Article
- Neurovirulence of Cryptococcus neoformans determined by time course of capsule accumulation and total volume of capsule in the brain.Journal of neurovirology · 2013Article
- Molecular and virulence characteristics of an outer membrane-associated RTX exoprotein in Pasteurella pneumotropica.BMC microbiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pasteurella pneumotropica can cause inflammation and abscess formation in a variety of tissues. Most commonly, P. pneumotropica produces clinical disease in immunodeficient mice or those concurrently infected with other pathogens. Because clinical disease is infrequent in immunocompetent mice harboring P. pneumotropica, some scientists consider it an opportunistic pathogen with little clinical relevance to biomedical research. However, other infectious agents, including mouse parvoviruses, mouse rotavirus, and Helicobacter spp. alter physiologic or biologic responses without causing clinical signs of illness. We investigated the potential for P. pneumotropica to modulate the transcription of cytokine genes in immunocompetent mice. In C57BL/6 mice inoculated oronasally with a minimal colonizing dose of P. pneumotropica, modest but statistically significant elevations of IL1beta, TNFalpha, CCL3, CXCL1, and CXCL2 mRNA were detected in mandibular and superficial cervical lymph nodes at 7 d after inoculation, and upregulation of IL1beta mRNA was detected 28 d after inoculation. These perturbations were not present in C57/BL6 mice inoculated with heat killed-P. pneumotropica or the related bacterium Actinobacillus muris. Nasal mucosal cytokine transcription did not vary significantly in C57BL/6 mice given a high dose of P. pneumotropica. These data indicate that slight and transient experimental perturbations are possible in immunocompetent mice colonized with P. pneumotropica. Knowing the full health status of experimental mice is paramount to avoid unwanted experimental variables, especially when using exquisitely sensitive testing methodologies such as those for quantification of gene expression.
Indexed as
Identifiers
20158944PMC2826080W11842390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.