ArticleThe international journal of neuropsychopharmacology2011
Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia.
Article in The international journal of neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 100 citations in OpenAlex.
- Early-Life Ventral Hippocampal Lesion and Circadian Disruption Result in Altered Behavior in Adult Mice in a Sex-Dependent Manner.The European journal of neuroscience · 2025Article
- Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar-Kyoto and Spontaneously Hypertensive Rats.Neurochemical research · 2024Article
- A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases.Cell discovery · 2021Article
- The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat.Frontiers in behavioral neuroscience · 2021Article
- Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/GαMolecular genetics and genomics : MGG · 2020Article
- Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sex Differences in Psychiatric Disease: A Focus on the Glutamate System.Frontiers in molecular neuroscience · 2018Review
- Sex-biased cellular signaling: molecular basis for sex differences in neuropsychiatric diseases.Dialogues in clinical neuroscience · 2016Review
- G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).The Journal of biological chemistry · 2015Article
- Overexpression of GRK6 rescues L-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats.Experimental neurology · 2015Article
- Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia.Schizophrenia research · 2014Article
- Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion.Frontiers in behavioral neuroscience · 2014Article
- Sex-specific cell signaling: the corticotropin-releasing factor receptor model.Trends in pharmacological sciences · 2013Review
- Sex-biased stress signaling: the corticotropin-releasing factor receptor as a model.Molecular pharmacology · 2013Review
- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.Pharmacology & therapeutics · 2012Review
- Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.PloS one · 2012Article
- Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling.Molecular pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animals with the neonatal ventral hippocampal lesion (NVHL) demonstrate altered responsiveness to stress and various drugs reminiscent of that in schizophrenia. Post-pubertal onset of abnormalities suggests the possibility of sex differences in NVHL effects that may model sex differences in schizophrenia. Here we demonstrate that novelty- and MK-801-induced hyperactivity is evident in both male and female NVHL rats, whereas only NVHL males were hyperactive in response to apomorphine. Next, we examined the sex- and NVHL-dependent differences in the activity of the ERK and Akt pathways. The basal activity of both pathways was higher in females than in males. NVHL reduces the level of phosphorylation of ERK1/2, Akt, and GSK-3 in both sexes, although males show more consistent down-regulation. Females had higher levels of G-protein-coupled kinases [G-protein-coupled receptor kinase (GRK)] 3 and 5, whereas the concentrations of other GRKs and arrestins were the same. In the nucleus accumbens, the concentration of GRK5 in females was elevated by NVHL to the male level. The data demonstrate profound sex differences in the expression and activity of signalling molecules that may underlie differential susceptibility to schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.