SynthesisBMC genomics2010
Bimodal gene expression patterns in breast cancer.
Synthesis in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Bayesian nonparametric estimation of targeted agent effects on biomarker change to predict clinical outcome.Biometrics · 2015Trial
- Bimodality in pan-cancer proteomics reveals new opportunities for biomarker discovery.Genome biology · 2026Article
- Article
- Bimodal Genomic Approach Predicting Semaphorin 7A (SEMA7A) as Prognostic Biomarker in Adrenocortical Carcinoma.Cancers · 2025Article
- Switch-like gene expression modulates disease risk.Nature communications · 2025Article
- Analogue information processing in NF-κB gene regulatory system.Royal Society open science · 2025Article
- Subgroup identification of targeted therapy effects on biomarker for time to event data.Cancer biomarkers : section A of Disease markers · 2023Article
- An integrated approach to identify bimodal genes associated with prognosis in câncer.Genetics and molecular biology · 2021Article
- Stochastic sequestration dynamics: a minimal model with extrinsic noise for bimodal distributions and competitors correlation.Scientific reports · 2018Article
- On the role of extrinsic noise in microRNA-mediated bimodal gene expression.PLoS computational biology · 2018Article
- MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells.Genome biology · 2017Article
- Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine.BMC genomics · 2016Article
- Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.BMC genomics · 2016Article
- Transcriptomic Biomarkers for Tuberculosis: Evaluation ofFrontiers in microbiology · 2016Article
- Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity.PloS one · 2014Article
- Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.Genome biology · 2013Article
- Mendelian and non-Mendelian regulation of gene expression in maize.PLoS genetics · 2013Article
- BiC: a web server for calculating bimodality of coexpression between gene and protein networks.Bioinformatics (Oxford, England) · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.