ArticleBMC genomics2010
Modeling neutral evolution of Alu elements using a branching process.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Patterns of piRNA Regulation in Drosophila Revealed through Transposable Element Clade Inference.Molecular biology and evolution · 2022Article
- Dynamics of Transposable Element Invasions with piRNA Clusters.Molecular biology and evolution · 2019Article
- Stochastic Hypothesis of Transition from Inborn Neutropenia to AML: Interactions of Cell Population Dynamics and Population Genetics.Frontiers in oncology · 2013Article
- Modeling neutral evolution of Alu elements using a branching process.BMC genomics · 2010Article
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2 authors.
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Abstract
backgroundAlu elements occupy about eleven percent of the human genome and are still growing in copy numbers. Since Alu elements substantially impact the shape of our genome, there is a need for modeling the amplification, mutation and selection forces of these elements.
methodsOur proposed theoretical neutral model follows a discrete-time branching process described by Griffiths and Pakes. From this model, we derive a limit frequency spectrum of the Alu element distribution, which serves as the theoretical, neutral frequency to which real Alu insertion data can be compared through statistical goodness of fit tests. Departures from the neutral frequency spectrum may indicate selection.
resultsA comparison of the Alu sequence data, obtained by courtesy of Dr. Jerzy Jurka, with our model shows that the distributions of Alu sequences in the AluY family systematically deviate from the expected distribution derived from the branching process.
conclusionsThis observation suggests that Alu sequences do not evolve neutrally and might be under selection.
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