ArticleTransfusion2010
Duration of red blood cell storage and survival of transfused patients (CME).
Article in Transfusion, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials.Haematologica · 2018Pooled it
- Pooled it
- Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review.Intensive care medicine · 2015Pooled it
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- Transfusion of older stored blood and risk of death: a meta-analysis.Transfusion · 2012Pooled it
- Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function.American journal of respiratory and critical care medicine · 2015Trial
- Effects of red-cell storage duration on patients undergoing cardiac surgery.The New England journal of medicine · 2015Trial
- Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients.Transfusion · 2015Trial
- Detection of microparticles from human red blood cells by multiparametric flow cytometry.Blood transfusion = Trasfusione del sangue · 2015Trial
- Ulinastatin, a protease inhibitor, may inhibit allogeneic blood transfusion-associated pro-inflammatory cytokines and systemic inflammatory response syndrome and improve postoperative recovery.Blood transfusion = Trasfusione del sangue · 2014Trial
- Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.Anesthesiology · 2012Trial
- Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.Anesthesia and analgesia · 2012Trial
- An agnostic study of donor and component factors associated with transfusion-related changes in laboratory markers.Transfusion · 2025Article
- Methodological considerations for linked blood donor-component-recipient analyses in transfusion medicine research.ISBT science series · 2020Article
- Association of blood group and red blood cell transfusion with the incidence of antepartum, peripartum and postpartum venous thromboembolism.Scientific reports · 2019Article
- The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.Trials · 2018Article
- Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Indications for and complications of transfusion and the management of gynecologic malignancies.Gynecologic oncology · 2017Review
- Association of Donor Age and Sex With Survival of Patients Receiving Transfusions.JAMA internal medicine · 2017Article
- Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.JCI insight · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
backgroundDisquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time. STUDY DESIGN AND
methodsWe conducted a cohort study utilizing data on all recipients of at least one RBC transfusion in Sweden and Denmark between 1995 and 2002, as recorded in the Scandinavian Donations and Transfusions (SCANDAT) database. Relative risks of death in relation to storage time were estimated using Cox regression, adjusted for several possible confounding factors.
resultsAfter various exclusions, 404,959 transfusion episodes remained for analysis. The 7-day risk of death was similar in all exposure groups, but a tendency for a higher risk emerged among recipients of blood stored for 30 to 42 days (hazard ratio, 1.05; 95% confidence interval [CI], 0.97-1.12), compared to recipients of blood stored for 10 to 19 days. With 2-year follow-up, this excess remained at the same level (hazard ratio, 1.05; 95% CI, 1.02-1.08). No dose-response pattern was revealed and no differential effect was seen when the analyses were restricted to recipients of leukoreduced units only.
conclusionAlthough a small excess mortality was noted in recipients of the oldest RBCs, the risk pattern was more consistent with weak confounding than with an effect of the momentary exposure to stored RBCs. It seems, thus, that any excess mortality conferred by older RBCs in the combined Swedish and Danish transfusion recipient population is likely less than 5%, which is considerably smaller than in the hitherto largest investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.