ArticleJournal of the American Geriatrics Society2010
Homocysteine and mobility in older adults.
Article in Journal of the American Geriatrics Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.PloS one · 2026Trial
- A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.Calcified tissue international · 2016Trial
- Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway.European journal of clinical nutrition · 2013Trial
- Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association of cardiovascular risk factors and intraplaque neovascularization in symptomatic carotid plaque.Frontiers in neurology · 2024Article
- Associations between Serum Folate Concentrations and Functional Disability in Older Adults.Antioxidants (Basel, Switzerland) · 2023Article
- Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.The American journal of clinical nutrition · 2021Article
- Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults.Frontiers in nutrition · 2021Article
- Sport Nutrigenomics: Personalized Nutrition for Athletic Performance.Frontiers in nutrition · 2019Review
- Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.The journal of nutrition, health & aging · 2017Article
- A comparison of power analysis methods for evaluating effects of a predictor on slopes in longitudinal designs with missing data.Statistical methods in medical research · 2015Article
- Vitamin B12, folic acid, and bone.Current osteoporosis reports · 2013Review
- Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons.The journal of nutrition, health & aging · 2013Article
- High-sensitivity C-reactive protein and mobility disability in older adults.Age and ageing · 2012Article
- Racial differences in gait velocity in an urban elderly cohort.Journal of the American Geriatrics Society · 2012Article
- Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons.European journal of clinical nutrition · 2012Article
- Homocysteine and the risk of nursing home admission and mortality in older persons.European journal of clinical nutrition · 2012Article
- Inflammatory markers and gait speed decline in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Predisability and gait patterns in older adults.Gait & posture · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine the influence of homocysteine on mobility decline in older adults.
designProspective cohort.
settingEinstein Aging Study, community-based aging study.
participantsFive hundred seventy-four older adults without dementia (mean age 80.2 +/- 5.4, 61% women). MEASUREMENTS: Mobility decline defined using gait velocity measurements at baseline and annual follow-up visits. Linear mixed effects models were used to adjust for age, sex, education, and other potential confounders.
resultsHigher homocysteine levels were associated with slower gait velocity at baseline. Adjusted for age, sex, and education, a one-unit increase in baseline log homocysteine levels was associated with a 2.95-cm/s faster mobility decline per year (P=.01) over a median follow-up of 1.4 years. The 140 subjects in the highest quartile of homocysteine had a faster rate of mobility decline (1.75 cm/s per year faster, P=.01) than the 434 subjects in the lowest three quartiles of homocysteine (<or=15 micromol/L). The association between homocysteine and mobility decline remained robust even after adjusting for multiple confounders and accounting for the presence of clinical gait abnormalities.
conclusionHigher homocysteine levels are associated with greater risk of mobility decline in community-residing older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.