ArticleJournal of the American Chemical Society2010
Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- Exploring the Mechanism of Action of Chicoric Acid Against Influenza Virus Infection Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.International journal of molecular sciences · 2025Article
- Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.Accounts of chemical research · 2019Article
- Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid.Bioorganic & medicinal chemistry letters · 2017Article
- Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.Journal of the American Chemical Society · 2017Article
- Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.Journal of medicinal chemistry · 2017Article
- Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.Chemical communications (Cambridge, England) · 2016Article
- Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.Journal of the American Chemical Society · 2016Article
- Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication.Scientific reports · 2015Article
- SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons.Neurotoxicity research · 2015Article
- Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.Biochemistry · 2014Article
- Benzoquinones as inhibitors of botulinum neurotoxin serotype A.Bioorganic & medicinal chemistry · 2014Article
- Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.Journal of computer-aided molecular design · 2014Article
- Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.Journal of medicinal chemistry · 2014Article
- Targeting botulinum A cellular toxicity: a prodrug approach.Journal of medicinal chemistry · 2013Article
- Review of the inhibition of biological activities of food-related selected toxins by natural compounds.Toxins · 2013Review
- The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.ACS medicinal chemistry letters · 2013Article
- Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.Chemistry & biology · 2012Article
- Tyrosine phosphorylation of botulinum neurotoxin protease domains.Frontiers in pharmacology · 2012Article
- Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.Bioorganic & medicinal chemistry letters · 2011Article
- A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.Chemical communications (Cambridge, England) · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A new mechanistic class of BoNT/A zinc metalloprotease inhibitors, from Echinacea, exemplified by the natural product d-chicoric acid (I1) is disclosed. A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the inhibitor binds to an exosite, displays noncompetitive partial inhibition, and is synergistic with a competitive active site inhibitor when used in combination. Other components found in Echinacea, I3 and I4, were also inhibitors of the protease.
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Registered trials
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