ArticleHuman genetics2010
A genome-wide survey does not show the genetic distinctiveness of Basques.
Article in Human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Genetic continuity in the Franco-Cantabrian region: new clues from autochthonous mitogenomes.PloS one · 2012Trial
- The Y chromosome of autochthonous Basque populations and the Bronze Age replacement.Scientific reports · 2021Article
- Rare human mitochondrial HV lineages spread from the Near East and Caucasus during post-LGM and Neolithic expansions.Scientific reports · 2019Article
- Sequence diversity of the Rh blood group system in Basques.European journal of human genetics : EJHG · 2018Article
- Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin.Biology of sex differences · 2016Article
- A Common Genetic Origin for Early Farmers from Mediterranean Cardial and Central European LBK Cultures.Molecular biology and evolution · 2015Article
- Across language families: Genome diversity mirrors linguistic variation within Europe.American journal of physical anthropology · 2015Article
- Demographic events and evolutionary forces shaping European genetic diversity.Cold Spring Harbor perspectives in biology · 2014Review
- Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population.BMC cancer · 2013Article
- The expanded mtDNA phylogeny of the Franco-Cantabrian region upholds the pre-neolithic genetic substrate of Basques.PloS one · 2013Article
- rs12512631 on the group specific complement (vitamin D-binding protein GC) implicated in melanoma susceptibility.PloS one · 2013Article
- Article
- The Basque paradigm: genetic evidence of a maternal continuity in the Franco-Cantabrian region since pre-Neolithic times.American journal of human genetics · 2012Article
- Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity.European journal of human genetics : EJHG · 2011Article
- Immunogenetics as a tool in anthropological studies.Immunology · 2011Review
- A customized pigmentation SNP array identifies a novel SNP associated with melanoma predisposition in the SLC45A2 gene.PloS one · 2011Article
- North African influences and potential bias in case-control association studies in the Spanish population.PloS one · 2011Article
- High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populations.Human genetics · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F (ST) distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.