ArticleJournal of modern optics2007
Detectors for single-molecule fluorescence imaging and spectroscopy.
Article in Journal of modern optics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed.
- Optimizing photon capture: advancements in amorphous silicon-based microchannel plates.Communications engineering · 2025Article
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- Fibrosis quantification using multiphoton excitation imaging of picrosirius red stained cardiac tissue.Research square · 2023Article
- Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array.Journal of biomedical optics · 2023Article
- Light sheet autofluorescence lifetime imaging with a single photon avalanche diode array.bioRxiv : the preprint server for biology · 2023Article
- Characterization of microchannel plate detector response for the detection of native multiply charged high mass single ions in orthogonal-time-of-flight mass spectrometry using a Timepix detector.Journal of mass spectrometry : JMS · 2022Article
- High Resolution Fluorescence Lifetime Maps from Minimal Photon Counts.ACS photonics · 2022Article
- Quantifying molecular- to cellular-level forces in living cells.Journal of physics D: Applied physics · 2021Article
- Custom silicon technology for SPAD-arrays with red-enhanced sensitivity and low timing jitter.Optics express · 2021Article
- Direct Photon-by-Photon Analysis of Time-Resolved Pulsed Excitation Data using Bayesian Nonparametrics.Cell reports. Physical science · 2020Article
- Single Virion Tracking Microscopy for the Study of Virus Entry Processes in Live Cells and Biomimetic Platforms.Advances in experimental medicine and biology · 2019Review
- Silicon technologies for arrays of Single Photon Avalanche Diodes.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells.Biomedical optics express · 2015Article
- Single molecule and single cell epigenomics.Methods (San Diego, Calif.) · 2015Review
- Silicon photon-counting avalanche diodes for single-molecule fluorescence spectroscopy.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society · 2014Article
- smFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand binding.FEBS letters · 2014Review
- Fabrication and characterization of monolithically integrated microchannel plates based on amorphous silicon.Scientific reports · 2014Article
- New silicon technologies enable high-performance arrays of Single Photon Avalanche Diodes.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- 8-spot smFRET analysis using two 8-pixel SPAD arrays.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- Development of new photon-counting detectors for single-molecule fluorescence microscopy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Single-molecule observation, characterization and manipulation techniques have recently come to the forefront of several research domains spanning chemistry, biology and physics. Due to the exquisite sensitivity, specificity, and unmasking of ensemble averaging, single-molecule fluorescence imaging and spectroscopy have become, in a short period of time, important tools in cell biology, biochemistry and biophysics. These methods led to new ways of thinking about biological processes such as viral infection, receptor diffusion and oligomerization, cellular signaling, protein-protein or protein-nucleic acid interactions, and molecular machines. Such achievements require a combination of several factors to be met, among which detector sensitivity and bandwidth are crucial. We examine here the needed performance of photodetectors used in these types of experiments, the current state of the art for different categories of detectors, and actual and future developments of single-photon counting detectors for single-molecule imaging and spectroscopy.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.