ArticleDatabase : the journal of biological databases and curation2009
The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases.
Article in Database : the journal of biological databases and curation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.PloS one · 2017Article
- Microglia regulate hippocampal neurogenesis during chronic neurodegeneration.Brain, behavior, and immunity · 2016Article
- A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.PloS one · 2016Article
- Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Identification of Major Signaling Pathways in Prion Disease Progression Using Network Analysis.PloS one · 2015Article
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- Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.PLoS pathogens · 2013Article
- Prion disease and the innate immune system.Viruses · 2012Review
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- Protease-resistant prions selectively decrease Shadoo protein.PLoS pathogens · 2011Article
- Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.PLoS pathogens · 2011Article
- Complement protein C1q forms a complex with cytotoxic prion protein oligomers.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Prion diseases reflect conformational conversion of benign isoforms of prion protein (PrP(C)) to malignant PrP(Sc) isoforms. Networks perturbed by PrP(Sc) accumulation and their ties to pathological events are poorly understood. Time-course transcriptomic and phenotypic data in animal models are critical for understanding prion-perturbed networks in systems biology studies. Here, we present the Prion Disease Database (PDDB), the most comprehensive data resource on mouse prion diseases to date. The PDDB contains: (i) time-course mRNA measurements spanning the interval from prion inoculation through appearance of clinical signs in eight mouse strain-prion strain combinations and (ii) histoblots showing temporal PrP(Sc) accumulation patterns in brains from each mouse-prion combination. To facilitate prion research, the PDDB also provides a suite of analytical tools for reconstructing dynamic networks via integration of temporal mRNA and interaction data and for analyzing these networks to generate hypotheses.Database URL:http://prion.systemsbiology.net.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.