ArticleJournal of ocular biology, diseases, and informatics2009
Metabolomic analysis of human disease and its application to the eye.
Article in Journal of ocular biology, diseases, and informatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy.BioMed research international · 2014Trial
- Metabolomic Changes in the Rat Eye Lens During the Cataract Onset.Molecules (Basel, Switzerland) · 2026Article
- Liquid Biopsy Combined with Multi-Omics Approaches in Diagnosis, Management, and Progression of Diabetic Retinopathy.Biomedicines · 2025Review
- Artificial Intelligence in Metabolomics: A Current Review.Trends in analytical chemistry : TRAC · 2024Article
- Metabolomics studies in common multifactorial eye disorders: a review of biomarker discovery for age-related macular degeneration, glaucoma, diabetic retinopathy and myopia.Frontiers in molecular biosciences · 2024Review
- Genetically Determined Metabolites in Graves Disease: Insight From a Mendelian Randomization Study.Journal of the Endocrine Society · 2023Article
- Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration.Aging · 2021Article
- Ocular growth and metabolomics are dependent upon the spectral content of ambient white light.Scientific reports · 2021Article
- Design and baseline data of a population-based metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation.Eye and vision (London, England) · 2020Article
- Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.PloS one · 2020Article
- A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease.Frontiers in cell and developmental biology · 2020Article
- Systematic review of differential methylation in rare ophthalmic diseases.BMJ open ophthalmology · 2019Review
- Effects of collagen cross-linking on the keratoconus metabolic network.Eye (London, England) · 2018Article
- Reprogramming the metabolome rescues retinal degeneration.Cellular and molecular life sciences : CMLS · 2018Review
- Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers.Ophthalmology · 2018Observational
- Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs.Scientific reports · 2017Article
- Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.Scientific reports · 2017Article
- Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy.PloS one · 2017Article
- Introduction to metabolomics and its applications in ophthalmology.Eye (London, England) · 2016Review
- An integrated mechanism of pediatric pseudotumor cerebri syndrome: evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics.Pediatric research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics, the analysis of the metabolite profile in body fluids or tissues, is being applied to the analysis of a number of different diseases as well as being used in following responses to therapy. While genomics involves the study of gene expression and proteomics the expression of proteins, metabolomics investigates the consequences of the activity of these genes and proteins. There is good reason to think that metabolomics will find particular utility in the investigation of inflammation, given the multi-layered responses to infection and damage that are seen. This may be particularly relevant to eye disease, which may have tissue specific and systemic components. Metabolomic analysis can inform us about ocular or other body fluids and can therefore provide new information on pathways and processes involved in these responses. In this review, we explore the metabolic consequences of disease, in particular ocular conditions, and why the data may be usefully and uniquely assessed using the multiplexed analysis inherent in the metabolomic approach.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.