ReviewJournal of Alzheimer's disease : JAD2010
Genetics of psychosis in Alzheimer's disease: a review.
Review in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood.Schizophrenia research · 2019Pooled it
- Genome-wide association study of Alzheimer's disease with psychotic symptoms.Molecular psychiatry · 2012Pooled it
- Review
- Correlations of psychological distress with plasma cytokine levels and gene mutations in acral and non-acral melanoma.Frontiers in psychiatry · 2022Article
- Searching for new drugs for the treatment of dementia-related psychosis.Postepy psychiatrii neurologii · 2021Review
- Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic.Scientific reports · 2020Article
- Psychosis in Alzheimer's Disease.Current neurology and neuroscience reports · 2020Review
- Genetic risk for schizophrenia and psychosis in Alzheimer disease.Molecular psychiatry · 2018Article
- Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease.Current Alzheimer research · 2018Article
- Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease.Neuroscience and biobehavioral reviews · 2017Review
- Genetics of psychosis of Alzheimer disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.Biochimica et biophysica acta · 2016Article
- Cognitive phenotype of psychotic symptoms in Alzheimer's disease: evidence for impaired visuoperceptual function in the misidentification subtype.International journal of geriatric psychiatry · 2015Article
- Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families.Neurobiology of aging · 2015Article
- Psychosis in Alzheimer's disease.Biological psychiatry · 2014Review
- Genetics of Psychosis in Alzheimer Disease.Current genetic medicine reports · 2014Article
- A rare duplication on chromosome 16p11.2 is identified in patients with psychosis in Alzheimer's disease.PloS one · 2014Article
- Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype.Behavioral and brain functions : BBF · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In and of itself, late-onset Alzheimer's disease (AD) can be a devastating illness. However, a sub-group of AD patients develop psychosis as the disease progresses. These patients have an added burden of greater cognitive impairment, higher rates of institutionalization, and higher mortality than AD patients without psychosis. While the etiopathogenesis such as psychosis in AD (AD+P) is not known, mounting evidence accrued over the past ten years indicates that AD+P represents a distinct phenotype with a genetic basis. Elucidating the genetic mechanism of AD+P is crucial if better pharmaceutical treatments are to be developed for these patients. The goal of this review is to summarize what is currently known regarding the genetic basis of psychosis in AD. Specific attention is given to familial aggregation and heritability, linkage to chromosomal loci, and associations of candidate genes of APOE and the monoamine neurotransmitter system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.