ArticleArchives of otolaryngology--head & neck surgery2010
Subglottic stenosis examined as a fibrotic response to airway injury characterized by altered mucosal fibroblast activity.
Article in Archives of otolaryngology--head & neck surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies.PloS one · 2017Pooled it
- Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025Review
- Revision tracheal resection anastomosis for recurrent stenosis after airway surgeries: functional outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The diagnostic accuracy of spirometry as screening tool for adult patients with a benign subglottic stenosis.BMC pulmonary medicine · 2023Article
- Sirolimus-eluting airway stent reduces profibrotic Th17 cells and inhibits laryngotracheal stenosis.JCI insight · 2023Article
- Laryngotracheal stenosis: Mechanistic review.Head & neck · 2022Review
- Serum interleukin 1β in patients with acquired laryngotracheal stenosis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults.International journal of molecular sciences · 2022Review
- The Effects of Rapamycin on the Proliferation, Migration, and Apoptosis of Human Tracheal Fibroblasts (HTrF) and Human Tracheal Epithelial Cells (HTEpiC).Journal of clinical medicine · 2022Article
- Paclitaxel-Loaded PLGA Coating Stents in the Treatment of Benign Cicatrical Airway Stenosis.Journal of clinical medicine · 2022Article
- How healthcare must respond to ventilator-associated pneumonia (VAP) in invasively mechanically ventilated COVID-19 patients.The American journal of emergency medicine · 2021Article
- Post-intubation subglottic stenosis: aetiology at the cellular and molecular level.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- [Risk factors affecting the surgical outcome of severe tracheal stenosis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Inflammatory pathways in the pathogenesis of iatrogenic laryngotracheal stenosis: what do we know?Translational cancer research · 2020Review
- Iatrogenic subglottic tracheal stenosis after tracheostomy and endotracheal intubation: A cohort observational study of more severity in keloid phenotype.Acta anaesthesiologica Scandinavica · 2019Observational
- Serial In-Office Intralesional Steroid Injections in Airway Stenosis.JAMA otolaryngology-- head & neck surgery · 2018Article
- Metabolic variations in normal and fibrotic human laryngotracheal-derived fibroblasts: A Warburg-like effect.The Laryngoscope · 2017Article
- Paclitaxel Drug-eluting Tracheal Stent Could Reduce Granulation Tissue Formation in a Canine Model.Chinese medical journal · 2016Article
- The role of Smad3 in the fibrotic phenotype in human vocal fold fibroblasts.The Laryngoscope · 2016Article
- Helical computed tomography scanning of the larynx and upper trachea in rabbits.Acta veterinaria Scandinavica · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the association between mucosal fibroblast activity and subglottic stenosis (SGS) development.
designProspective study of an animal model of SGS.
settingAcademic research laboratory. SUBJECTS: New Zealand white rabbits were assigned to either the cricothyroidotomy and carbon dioxide laser injury group or the cricothyroidotomy and silver nitrate injury group. Airways were excised for histologic analysis and the establishment of primary fibroblast cultures. Lesions from surgical excision of established SGS and subglottic tissue were used to analyze SGS recurrence.
interventionsThe subglottis was approached via cricothyroidotomy and was subjected to either carbon dioxide laser or silver nitrate injury before closure. The SGS lesions were excised at 8 to 10 weeks and were used to establish explants for fibroblast culture. The animals underwent recovery for an additional 14 days to follow recurrence of SGS. After 14 days, all the animals were killed humanely, and subglottic tissue was harvested for histologic evaluation. Rates of migration and contraction of SGS and normal airway fibroblasts were assayed using established in vitro methods under basal conditions and with prostaglandin E(2) treatment.
main outcome measuresFor in vivo studies, injury, healing, and scarring of the mucosa and cartilage were the primary measures. For cultured fibroblast experiments, cellular responses of fibroblasts from normal and stenosed mucosa were compared and contrasted.
resultsMucosal injury resulted in acute fibroplasia and chronic SGS, surgical excision of mature SGS at 8 weeks resulted in rapid recurrence of stenosis, and SGS-derived fibroblasts were relatively refractory to the effects of prostaglandin E(2) on migration and contraction.
conclusionsSubglottic stenosis represents a fibrotic airway repair process that involves fibroblasts that produce recurrent, excessive scar formation. We suggest that SGS development and recurrence may be partially dictated by altered fibroblast responsiveness to antifibroplastic signals during mucosal repair.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.