ArticleThe Journal of physiology2010
Human vagal baroreflex mechanisms in space.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Lower-body positive pressure diminishes surface blood flow reactivity during treadmill walking.BMC research notes · 2019Trial
- Sex-based differences in central and cerebral hemodynamic responses to lower body negative pressure (LBNP): an experimental study.European journal of applied physiology · 2026Article
- Cardiovascular response of children to 1 hour of microgravity simulation-a pioneering study.NPJ microgravity · 2026Article
- Three-week dry immersion results in a more severe impairment of cardiac baroreflex than head-down bed rest of the same duration.European journal of applied physiology · 2026Article
- Spontaneous indices correlate with baroreflex gain only in adults with spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Gastrointestinal motility in microgravity: a critical review of multi-level mechanisms and model-dependent effects.Frontiers in physiology · 2026Review
- Simulated microgravity exposure markedly attenuates the baroreflex total loop gain and induces orthostatic hypotension in male rats.Physiological reports · 2025Article
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- [Risks, mechanisms, and prevention strategies for cerebrovascular diseases in lunar astronauts under deep].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Lower body negative pressure identifies altered central vein characteristics without accompanying changes to baroreflexes in astronauts within hours of landing.Scientific reports · 2024Article
- Influence of a Passive Tilt Test on the Proteomic Composition of the Blood of Healthy Humans.Bulletin of experimental biology and medicine · 2024Article
- Response of cardiac pulse parameters in humans at various inclinations via 360° rotating platform for simulated microgravity perspective.NPJ microgravity · 2023Article
- Impacts of microgravity on amino acid metabolism during spaceflight.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Cardiac function, structural, and electrical remodeling by microgravity exposure.American journal of physiology. Heart and circulatory physiology · 2023Review
- Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.Frontiers in cardiovascular medicine · 2023Article
- Indirect measurement of absolute cardiac output during exercise in simulated altered gravity is highly dependent on the method.Journal of clinical monitoring and computing · 2022Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although astronauts' cardiovascular function is normal while they are in space, many have altered haemodynamic responses to standing after they return to Earth, including inordinate tachycardia, orthostatic hypotension, and uncommonly, syncope. Simulated microgravity impairs vagal baroreceptor-cardiac reflex function and causes orthostatic hypotension. Actual microgravity, however, has been shown to either increase, or not change vagal baroreflex gain. In this study, we tested the null hypothesis that spaceflight does not impair human baroreflex mechanisms. We studied 11 American and two German astronauts before, during (flight days 2-8), and after two, 9- and 10-day space shuttle missions, with graded neck pressure and suction, to elicit sigmoid, vagally mediated carotid baroreflex R-R interval responses. Baseline systolic pressures tended to be higher in space than on Earth (P = 0.015, repeated measures analysis of variance), and baseline R-R intervals tended to be lower (P = 0.049). Baroreceptor-cardiac reflex relations were displaced downward on the R-R interval axis in space. The average range of R-R interval responses to neck pressure changes declined from preflight levels by 37% on flight day 8 (P = 0.051), maximum R-R intervals declined by 14% (P = 0.003), and vagal baroreflex gain by 9% (P = 0.009). These measures returned to preflight levels by 7-10 days after astronauts returned to Earth. This study documents significant increases of arterial pressure and impairment of vagal baroreflex function in space. These results and results published earlier indicate that microgravity exposure augments sympathetic, and diminishes vagal cardiovascular influences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.