ArticleEuropean journal of medical research2009
Factors attributable to the level of exhaled nitric oxide in asthmatic children.
Article in European journal of medical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Establishing IMMULITE® 2000 cut-off values for serum allergen-specific immunoglobulin and exploring their relationship to exhaled nitric oxide.Acta paediatrica (Oslo, Norway : 1992) · 2014Trial
- Role of exhaled nitric oxide as a predictor of atopy.Respiratory research · 2013Trial
- Reference values for exhaled nitric oxide in healthy children aged 6-18 years in China: a cross-sectional, multicenter clinical study.Respiratory research · 2024Article
- Oxidative Stress and Bronchial Asthma in Children-Causes or Consequences?Frontiers in pediatrics · 2017Review
- Normal values of nasal NO and exhaled NO in young Chinese people aged 9 - 22 years.World journal of otorhinolaryngology - head and neck surgery · 2016Article
- Relationships between exhaled nitric oxide and atopy profiles in children with asthma.Allergy, asthma & immunology research · 2013Article
- Personalised medicine and asthma diagnostics/management.Current allergy and asthma reports · 2013Review
- Clinical update on the use of biomarkers of airway inflammation in the management of asthma.Journal of asthma and allergy · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a heterogeneous disease with variable symptoms especially in children. Exhaled nitric oxide (FeNO) has proved to be a marker of inflammation in the airways and has become a substantial part of clinical management of asthmatic children due to its potential to predict possible exacerbation and adjust the dose of inhalant corticosteroids.
objectivesWe analyzed potential factors that contribute to the variability of nitric oxide in various clinical and laboratory conditions. MATERIAL AND
methodsStudy population consisted of 222 asthmatic children and 27 healthy control subjects. All children underwent a panel of tests: fractioned exhaled nitric oxide, exhaled carbon monoxide, asthma control test scoring, blood sampling, skin prick tests, and basic spirometry.
resultsFeNO and other investigated parameters widely changed according to clinical or laboratory characteristics of the tested children. Asthmatics showed increased levels of FeNO, exhaled carbon monoxide, total serum IgE, and higher eosinophilia. Boys had higher FeNO levels than girls. We found a significant positive correlation between FeNO levels and the percentage of blood eosinophils, %predicted of forced vital capacity, total serum IgE levels, and increasing age.
conclusionsVarious phenotypes of children's asthma are characterized by specific pattern of the results of clinical and laboratory tests. FeNO correlates with total serum IgE, blood eosinophilia, age, and some spirometric parameters with different strength. Therefore, the coexistence of atopy, concomitant allergic rhinitis/rhinoconjunctivitis, and some other parameters should be considered in critical evaluation of FeNO in the management of asthmatic children.
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