ReviewOral surgery, oral medicine, oral pathology, oral radiology, and endodontics2010
Oropharyngeal candidiasis in the era of antiretroviral therapy.
Review in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Drug-resistant oral candidiasis in patients with HIV infection: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Resistance profiles to antifungal agents in Candida albicans isolated from human oral cavities: systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Epidemiology of Invasive Candidiasis.Clinical epidemiology · 2024Review
- Protective Properties of S-layer Protein 2 fromBiomolecules · 2023Article
- Denture Stomatitis and Candida albicans in the Indian Population: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Effects of Nystatin oral rinse on oral Candida species and Streptococcus mutans among healthy adults.Clinical oral investigations · 2023Article
- Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes.Antibiotics (Basel, Switzerland) · 2023Review
- Review
- Candida Infection Associated with Anti-IL-17 Medication: A Systematic Analysis and Review of the Literature.American journal of clinical dermatology · 2022Review
- Prevalence ofJournal of pharmacy & bioallied sciences · 2022Article
- Effects of benzydamine and mouthwashes containing benzydamine on Candida albicans adhesion, biofilm formation, regrowth, and persistence.Clinical oral investigations · 2022Article
- Comparative Efficacy and Safety of Antifungal Agents in the Prophylaxis of Oropharyngeal Candidiasis among HIV-Infected Adults: A Systematic Review and Network Meta-Analysis.Life (Basel, Switzerland) · 2022Review
- Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity.Frontiers in immunology · 2022Review
- Alterations in the oral microbiome in HIV infection: causes, effects and potential interventions.Chinese medical journal · 2021Review
- Comparative Efficacy of Antifungal Agents Used in the Treatment of Oropharyngeal Candidiasis among HIV-Infected Adults: A Systematic Review and Network Meta-Analysis.Journal of fungi (Basel, Switzerland) · 2021Review
- Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management.Journal of fungi (Basel, Switzerland) · 2021Review
- Efficacy of clotrimazole for the management of oral candidiasis: A meta-analysis of randomized clinical trials.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- A Second-Generation Fungerp Analog, SCY-247, Shows PotentAntimicrobial agents and chemotherapy · 2021Article
- HPLC-MS identification and expression ofAIMS microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Oropharyngeal candidiasis (OPC) remains a common problem in the HIV-infected population despite the availability of antiretroviral therapy (ART). Although Candida albicans is the most frequently implicated pathogen, other Candida species also may cause infection. The emergence of antifungal resistance within these causative yeasts, especially in patients with recurrent oropharyngeal infection or with long-term use of antifungal therapies, requires a working knowledge of alternative antifungal agents. Identification of the infecting organism and antifungal susceptibility testing enhances the ability of clinicians to prescribe appropriate antifungal therapy. Characterization of the responsible mechanisms has improved our understanding of the development of antifungal resistance and could enhance the management of these infections. Immune reconstitution has been shown to reduce rates of OPC, but few studies have evaluated the current impact of ART on the epidemiology of OPC and antifungal resistance in these patients. Preliminary results from an ongoing clinical study showed that in patients with advanced AIDS, oral yeast colonization was extensive, occurring in 81.1% of the 122 patients studied, and symptomatic infection occurred in one-third. In addition, resistant yeasts were still common, occurring in 25.3% of patients colonized with yeasts or with symptomatic infection. Thus, OPC remains a significant infection in advanced AIDS, even with ART. Current knowledge of the epidemiology, pathogenesis, clinical presentation, treatment, and mechanisms of antifungal resistance observed in OPC are important in managing patients with this infection and are the focus of this review.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.