Evidence map›Paper›PMID 20156643›Full record

ReviewThrombosis research2010

Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.

Usha R Pendurthi, L Vijaya Mohan Rao

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Thrombosis research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Protein C anticoagulant and cytoprotective pathways.International journal of hematology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Usha R PendurthiCenter for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA. usha.pendurthi@uthct.edu
L Vijaya Mohan Rao
The University of Texas Health Science Center at Tyler · US

Funding

INITIATION AND REGULATION OF BLOOD COAGULATIONR01HL058869 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI LELLA, VIJAYA MOHAN RAO · 1998 to 2010
$2.3M
Tissue Factor-factor Vlla signalingR01HL065500 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI PENDURTHI, USHA R · 2001 to 2010
$1.8M
NHLBI NIH HHS HL58869NHLBI NIH HHS HL65550NHLBI NIH HHS R01 HL058869NHLBI NIH HHS R01 HL065500
6 · The paper itself

Abstract

Plasma coagulation factor VIIa (FVIIa) initiates the coagulation cascade by binding to its cofactor, tissue factor (TF) on cell surfaces, which eventually leads to fibrin deposition and platelet activation. Recent studies showed that FVIIa also binds to endothelial cell protein C receptor (EPCR), a known cellular receptor for anticoagulant protein C\activated protein C, on the endothelium. The present article reviews our current knowledge of FVIIa interaction with EPCR and discusses the potential significance of this interaction in hemostasis, treatment of bleeding disorders with pharmacological doses of FVIIa and FVIIa clearance.

Indexed as

Gene Expression RegulationBinding SitesBlood Coagulation FactorsEndothelial CellsEndothelium, VascularFactor VIIaFibrinHemophilia AHemostasisHumansModels, BiologicalReceptors, Cell SurfaceThromboplastinactivated protein C receptorBlood Coagulation FactorsFactor VIIaFibrinReceptors, Cell SurfaceThromboplastin

Identifiers

PMID20156643
PMCPMC2838982
OpenAlexW1968715313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.