Evidence map›Paper›PMID 20156504›Full record

ReviewNeurochemistry international2010

Regulated exocytosis in astrocytic signal integration.

Vladimir Parpura, Brandi J Baker, Matjaz Jeras, Robert Zorec

Open access · greenAbstract readReview
In one paragraph

Review in Neurochemistry international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Astrocytes in Flavivirus Infections.International journal of molecular sciences · 2019
    Review
  5. Astrocyte, a Promising Target for Mood Disorder Interventions.Frontiers in molecular neuroscience · 2019
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.Journal of neural transmission (Vienna, Austria : 1996) · 2016
    Review
  11. Article
  12. Article
  13. Brain oscillations in bipolar disorder and lithium-induced changes.Neuropsychiatric disease and treatment · 2016
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Vladimir ParpuraDepartment of Neurobiology, University of Alabama, Birmingham, AL 35294-0021, USA. vlad@uab.edu
Brandi J Baker
Matjaz Jeras
Robert Zorec
University of Ljubljana · SIUniversity of Alabama · USUniversity of Alabama at Birmingham · US

Funding

Calcium-dependent glutamate release from astrocytesR01MH069791 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PARPURA, VLADIMIR · 2004 to 2008
$1.2M
NIMH NIH HHS R01 MH 069791NIMH NIH HHS R01 MH069791
6 · The paper itself

Abstract

Astrocytes can be considered as signal integrators in central nervous system activity. These glial cells can respond to signals from the heterocellular milieu of the brain and subsequently release various molecules to signal to themselves and/or other neighboring neural cells. An important functional module that enables signal integration in astrocytes is exocytosis, a Ca(2+)-dependent process consisting of vesicular fusion to the plasma membrane. Astrocytes utilize regulated exocytosis to release various signaling molecules stored in the vesicular lumen. Here we review the properties of exocytotic release of three classes of gliotransmitters: (i) amino acids, (ii) nucleotides and (iii) peptides. Vesicles may carry not only lumenal cargo, but also membrane-associated molecules. Therefore, we also discuss exocytosis as a delivery mechanism for transporters and receptors to the plasma membrane, where these proteins are involved in astrocytic intercellular signaling.

Indexed as

Adenosine TriphosphateAmino AcidsAnimalsAstrocytesCell MembraneExocytosisHumansNeuropeptidesSignal TransductionAdenosine TriphosphateAmino AcidsNeuropeptides

Identifiers

PMID20156504
PMCPMC2892557
OpenAlexW1990007003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.