ReviewSteroids2010
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action.
Review in Steroids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 127 citations in OpenAlex.
- Integrated hormonal, metabolic, and epigenetic regulation of corpus luteum function: insights into steroidogenesis, angiogenesis, and regression.Frontiers in endocrinology · 2026Review
- PCOS and the Genome: Is the Genetic Puzzle Still Worth Solving?Biomedicines · 2025Review
- Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau.Cell discovery · 2025Article
- Article
- Global metabolomics study on the pathogenesis of pediatric medulloblastoma via UPLC- Q/E-MS/MS.PloS one · 2023Article
- Plasma metabolites associated with physiological and biochemical indexes indicate the effect of caging stress on mallard ducks (Anas platyrhynchos).Animal bioscience · 2022Article
- Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†.Biology of reproduction · 2020Article
- Effects and Mechanisms of Phthalates' Action on Reproductive Processes and Reproductive Health: A Literature Review.International journal of environmental research and public health · 2020Review
- Proteomic analysis revealed common, unique and systemic signatures in gender-dependent hepatocarcinogenesis.Biology of sex differences · 2020Article
- Can trophectoderm RNA analysis predict human blastocyst competency?Systems biology in reproductive medicine · 2019Article
- Corticosterone rather than ethanol epigenetic programmed testicular dysplasia caused by prenatal ethanol exposure in male offspring rats.Epigenetics · 2019Article
- Maternal betaine suppresses adrenal expression of cholesterol trafficking genes and decreases plasma corticosterone concentration in offspring pullets.Journal of animal science and biotechnology · 2019Article
- De novo transcriptome of the mayfly Cloeon viridulum and transcriptional signatures of Prometabola.PloS one · 2017Article
- Nicotine Suppressed Fetal Adrenal StAR Expression via YY1 Mediated-Histone Deacetylation Modification Mechanism.International journal of molecular sciences · 2016Article
- Changes in gene expression of histone modification enzymes in rat granulosa cells undergoing luteinization during ovulation.Journal of ovarian research · 2016Article
- Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland.Frontiers in endocrinology · 2015Review
- Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups.American journal of physiology. Endocrinology and metabolism · 2014Article
- Article
- The opposing roles of nitric oxide and cGMP in the age-associated decline in rat testicular steroidogenesis.Endocrinology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Steroid hormones participate in organ development, reproduction, body homeostasis, and stress responses. The steroid machinery is expressed in a development- and tissue-specific manner, with the expression of these factors being tightly regulated by an array of transcription factors (TFs). Epigenetics provides an additional layer of gene regulation through DNA methylation and histone tail modifications. Evidence of epigenetic regulation of key steroidogenic enzymes is increasing, though this does not seem to be a predominant regulatory pathway. Steroid hormones exert their action in target tissues through steroid nuclear receptors belonging to the NR3A and NR3C families. Nuclear receptor expression levels and post-translational modifications regulate their function and dictate their sensitivity to steroid ligands. Nuclear receptors and TFs are more likely to be epigenetically regulated than proteins involved in steroidogenesis and have secondary impact on the expression of these steroidogenic enzymes. Here we review evidence for epigenetic regulation of enzymes, transcription factors, and nuclear receptors related to steroid biogenesis and action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.