ArticleMalaria journal2010
Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children.
Article in Malaria journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.
- Pooled it
- A review of the effects of artemether-lumefantrine on gametocyte carriage and disease transmission.Malaria journal · 2014Pooled it
- Trial
- Review
- Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana.Malaria journal · 2023Article
- Assessment of the Antimalarial Treatment Failure in Ebonyi State, Southeast Nigeria.Journal of xenobiotics · 2023Article
- Liposomes for malaria management: the evolution from 1980 to 2020.Malaria journal · 2021Review
- Predictors of treatment failures of plasmodium falciparum malaria in Vietnam: a 4-year single-centre retrospective study.Malaria journal · 2021Article
- Impacts of Antimalarial Drugs onThe American journal of tropical medicine and hygiene · 2018Article
- Review
- Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.Evolutionary applications · 2015Article
- Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites.PLoS pathogens · 2014Article
- Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon.Antimicrobial agents and chemotherapy · 2014Article
- Improving pharmacokinetic-pharmacodynamic modeling to investigate anti-infective chemotherapy with application to the current generation of antimalarial drugs.PLoS computational biology · 2013Article
- Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana.Malaria journal · 2012Article
- Delayed Plasmodium falciparum clearance following artesunate-mefloquine combination therapy in Thailand, 1997-2007.Malaria journal · 2012Article
- No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.The American journal of tropical medicine and hygiene · 2012Article
- Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children.BMC infectious diseases · 2011Article
- Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments.The American journal of tropical medicine and hygiene · 2011Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDrug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children.
methodsThe factors contributing to delay in parasite clearance, defined as a clearance time > 2 d, in falciparum malaria were characterized in 2,752 prospectively studied children treated with anti-malarial drugs between 1996 and 2008.
results1,237 of 2,752 children (45%) had delay in parasite clearance. Overall 211 children (17%) with delay in clearance subsequently failed therapy and they constituted 72% of those who had drug failure, i.e., 211 of 291 children. The following were independent risk factors for delay in parasite clearance at enrolment: age less than or equal to 2 years (Adjusted odds ratio [AOR] = 2.13, 95% confidence interval [CI]1.44-3.15, P < 0.0001), presence of fever (AOR = 1.33, 95% CI = 1.04-1.69, P = 0.019), parasitaemia >50,000/ul (AOR = 2.21, 95% CI = 1.77-2.75, P < 0.0001), and enrolment before year 2000 (AOR= 1.55, 95% CI = 1.22-1.96, P < 0.0001). Following treatment, a body temperature >or= 38 degrees C and parasitaemia > 20000/microl a day after treatment began, were independent risk factors for delay in clearance. Non-artemisinin monotherapies were associated with delay in clearance and treatment failures, and in those treated with chloroquine or amodiaquine, with pfmdr 1/pfcrt mutants. Delay in clearance significantly increased gametocyte carriage (P < 0.0001).
conclusionDelay in parasite clearance is multifactorial, is related to drug resistance and treatment failure in uncomplicated malaria and has implications for malaria control efforts in sub-Saharan Africa.
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