ArticleEvolution & development
Phylogenetic analysis of developmental and postnatal mouse cell lineages.
Article in Evolution & development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Stereotyped Subclones Revealed by High-Density Single-Cell Lineage Tracing Support Robust Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes.Nature biotechnology · 2024Article
- PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types.iScience · 2020Article
- Building a lineage from single cells: genetic techniques for cell lineage tracking.Nature reviews. Genetics · 2017Review
- A generic, cost-effective, and scalable cell lineage analysis platform.Genome research · 2016Article
- Accuracy of Answers to Cell Lineage Questions Depends on Single-Cell Genomics Data Quality and Quantity.PLoS computational biology · 2016Article
- Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers.Transgenic research · 2015Article
- Using tumour phylogenetics to identify the roots of metastasis in humans.Nature reviews. Clinical oncology · 2015Review
- Determinative developmental cell lineages are robust to cell deaths.PLoS genetics · 2014Article
- Hypermutable DNA chronicles the evolution of human colon cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Single-cell sequencing-based technologies will revolutionize whole-organism science.Nature reviews. Genetics · 2013Review
- Article
- Comparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutations.PLoS computational biology · 2013Article
- I. Embryonal vasculature formation recapitulated in transgenic mammary tumor spheroids implanted pseudo-orthotopicly into mouse dorsal skin fold: the organoblasts concept.F1000Research · 2013Article
- Cell lineage analysis of the mammalian female germline.PLoS genetics · 2012Article
- Decoding cell lineage from acquired mutations using arbitrary deep sequencing.Nature methods · 2011Article
- Colon stem cell and crypt dynamics exposed by cell lineage reconstruction.PLoS genetics · 2011Article
- Muscle-bound primordial stem cells give rise to myofiber-associated myogenic and non-myogenic progenitors.PloS one · 2011Article
- Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.Seminars in cancer biology · 2010Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
Fate maps depict how cells relate together through past lineage relationships, and are useful tools for studying developmental and somatic processes. However, with existing technologies, it has not been possible to generate detailed fate maps of complex organisms such as the mouse. We and others have therefore proposed a novel approach, "phylogenetic fate mapping," where patterns of somatic mutation carried by the individual cells of an animal are used to retrospectively deduce lineage relationships through phylogenetic inference. Here, we have cataloged genomic polymorphisms at 324 mutation-prone polyguanine tracts for nearly 300 cells isolated from a single mouse, and have explored the cells' lineage relationships both phylogenetically and through a network-based approach. We present a model of mouse embryogenesis, where an early period of substantial cell mixing is followed by more coherent growth of clones later. We find that cells from certain tissues have greater numbers of close relatives in other specific tissues than expected from chance, suggesting that those populations arise from a similar pool of ancestral lineages. Finally, we have investigated the dynamics of cell turnover (the frequency of cell loss and replacement) in postnatal tissues. This work offers a longitudinal study of developmental lineages, from conception to adulthood, and provides insight into basic questions of mouse embryology as well as the somatic processes that occur after birth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.