ArticleAIDS research and human retroviruses2010
Predictors of success with highly active antiretroviral therapy in an antiretroviral-naive urban population.
Article in AIDS research and human retroviruses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Factors associated with antiretroviral treatment failure among people living with HIV on antiretroviral therapy in resource-poor settings: a systematic review and metaanalysis.Systematic reviews · 2020Pooled it
- Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.AIDS and behavior · 2014Pooled it
- Diagnostic and Therapeutic Perspectives on Persistent HIV-1 Low-Level Viremia.Infection & chemotherapy · 2026Review
- Success rates and adherence to antiretroviral therapy among treatment-naïve patients in Davao City, Philippines: A ten-year retrospective cohort study.Dialogues in health · 2024Article
- Socioeconomic Status and CD4 Count Among People with HIV Who Inject Drugs in St. Petersburg, Russia.AIDS and behavior · 2024Article
- Article
- Socioeconomic disparity of immunologic outcome among people living with HIV in Guangxi, China.AIDS care · 2021Article
- The Role of Stigma Management in HIV Treatment Adherence.International journal of environmental research and public health · 2019Article
- Cost-effectiveness of HIV care coordination scale-up among persons at high risk for sub-optimal HIV care outcomes.PloS one · 2019Article
- Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy.AIDS (London, England) · 2018Article
- Socioeconomic status and treatment outcomes for individuals with HIV on antiretroviral treatment in the UK: cross-sectional and longitudinal analyses.The Lancet. Public health · 2016Article
- Second-Line HIV Therapy Outcomes and Determinants of Mortality at the Largest HIV Referral Center in Southern Vietnam.Medicine · 2015Observational
- Differences in Response to Antiretroviral Therapy by Sex and Hepatitis C Infection Status.AIDS patient care and STDs · 2015Article
- Improvements in HIV care engagement and viral load suppression following enrollment in a comprehensive HIV care coordination program.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Factors associated with high transmission risk and detectable plasma HIV RNA in HIV-infected MSM on ART.International journal of STD & AIDS · 2014Article
- Cervical cancer screening adherence among HIV-positive female smokers from a comprehensive HIV clinic.AIDS and behavior · 2014Article
- Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil.AIDS research and therapy · 2014Article
- Retention and risk factors for attrition in a large public health ART program in Myanmar: a retrospective cohort analysis.PloS one · 2014Article
- Shifting the paradigm: using HIV surveillance data as a foundation for improving HIV care and preventing HIV infection.The Milbank quarterly · 2013Article
- Progress realized: trends in HIV-1 viral load and CD4 cell count in a tertiary-care center from 1999 through 2011.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Abstract Predictors of successful virologic, immunologic, and clinical response with combined antiretroviral therapy (cART) containing a boosted protease inhibitor or a nonnucleoside reverse transcriptase inhibitor were analyzed among an antiretroviral naive (ARV-naive) urban cohort. Measures of success included virologic suppression [HIV-1 viral load (VL) <400 copies/ml], an increase in CD4(+) T cells from baseline of >100 cells/microl, and lack of development of an AIDS-defining illness at 24 and 48 weeks after cART initiation. Two hundred and eighty-seven ARV-naive patients were included in this cohort, of which 76.7% were male and 86.8% were nonwhite. At the time of cART initiation their median age was 39 years, the geometric mean CD4(+) count was 42 cells/microl, and the mean viral load was 5.3 log(10) copies/ml. At 48 weeks, 72% of patients achieved virologic suppression, with > or =90% adherence and high school graduation predicting viral undetectability at 48 weeks. Baseline VL < or =100,000 copies/ml and a CD4(+) cell count >100 cells/microl were associated with viral suppression at 24 weeks [OR (95% CI) = 3.55 (1.29-9.81) and 3.96 (1.19-13.15), respectively]; female gender was associated with a greater increase in CD4(+) cell counts [OR (95% CI) = 7.41 (2.48-22.1)]. CDC stage A1-C2 at baseline predicted lack of clinical progression at 48 weeks. The results of this analysis of an ARV-naive cohort comprised predominantly of indigent, minority patients suggest that men who did not have a high school education and who had advanced HIV infection are less likely to have therapeutic success after cART initiation.
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