ArticleACS nano2010
Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay.
Article in ACS nano, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 236 citations in OpenAlex.
- Toward point-of-care cancer diagnostics: gold nanoparticle-based colorimetric sensors.RSC advances · 2026Review
- Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy.Nanoscale advances · 2024Review
- Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review.Sensors (Basel, Switzerland) · 2023Review
- Biosensor Design for the Detection of Circulating Tumor Cells Using the Quartz Crystal Resonator Technique.Biosensors · 2023Article
- Porphyrin-Based Covalent Organic Frameworks with Donor-Acceptor Structure for Enhanced Peroxidase-like Activity as a Colorimetric Biosensing Platform.Biosensors · 2023Article
- Label-free fluorescent aptasensor for chloramphenicol based on hybridization chain reaction amplification and G-quadruplex/RSC advances · 2022Article
- Smartphone-based surface plasmon resonance sensing platform for rapid detection of bacteria.RSC advances · 2022Article
- Three-dimensional porous calcium alginate fluorescence bead-based immunoassay for highly sensitive early diagnosis of breast cancer.Analytical and bioanalytical chemistry · 2022Article
- Gold-iron oxide nanohybrids: insights into colloidal stability and surface-enhanced Raman detection.Nanoscale advances · 2021Article
- The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles.Nanoscale advances · 2021Article
- Review
- A sensitive fluorometric sensor for AgRSC advances · 2020Article
- The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment.International journal of molecular sciences · 2020Review
- Sensitive fluorometric determination of platelet-derived growth factor BB and avian influenza A virus DNA via dual signal amplification using the hybridization chain reaction and glucose oxidase assisted recycling.Mikrochimica acta · 2019Article
- Optical assays based on colloidal inorganic nanoparticles.The Analyst · 2018Review
- Decoupled in-plane Dipole Resonance Modulated Colorimetric Assay-Based Optical Ruler for Ultra-Trace Gold (Au) Detection.Scientific reports · 2018Article
- Determination of brain injury biomarkers by surface-enhanced Raman scattering using hollow gold nanospheres.RSC advances · 2018Article
- Microscopic Differentiation of Plasmonic Nanoparticles for the Ratiometric Read-out of Target DNA.Scientific reports · 2017Article
- Rapid and PCR-free DNA Detection by Nanoaggregation-Enhanced Chemiluminescence.Scientific reports · 2017Article
- Aptamer Cell-Based Selection: Overview and Advances.Biomedicines · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Breast cancer is the most common cancer among women, and it is the second leading cause of cancer deaths in women today. The key to the effective and ultimately successful treatment of diseases such as cancer is early and accurate diagnosis. Driven by the need, in this article, we report for the first time a simple colorimetric and highly sensitive two-photon scattering assay for highly selective and sensitive detection of breast cancer SK-BR-3 cell lines at a 100 cells/mL level using a multifunctional (monoclonal anti-HER2/c-erb-2 antibody and S6 RNA aptamer-conjugated) oval-shaped gold-nanoparticle-based nanoconjugate. When multifunctional oval-shaped gold nanoparticles are mixed with the breast cancer SK-BR-3 cell line, a distinct color change occurs and two-photon scattering intensity increases by about 13 times. Experimental data with the HaCaT noncancerous cell line, as well as with MDA-MB-231 breast cancer cell line, clearly demonstrated that our assay was highly sensitive to SK-BR-3 and it was able to distinguish from other breast cancer cell lines that express low levels of HER2. The mechanism of selectivity and the assay's response change have been discussed. Our experimental results reported here open up a new possibility of rapid, easy, and reliable diagnosis of cancer cell lines by monitoring the colorimetric change and measuring TPS intensity from multifunctional gold nanosystems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.