ReviewAnalytical and bioanalytical chemistry2010
Oxidative protein labeling in mass-spectrometry-based proteomics.
Review in Analytical and bioanalytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Protein Adducts and Protein Oxidation as Molecular Mechanisms of Flavonoid Bioactivity.Molecules (Basel, Switzerland) · 2021Review
- The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.Redox biology · 2018Article
- The Role of Mass Spectrometry in Structural Studies of Flavin-Based Electron Bifurcating Enzymes.Frontiers in microbiology · 2018Review
- Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.Nature protocols · 2017Article
- The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.The Journal of biological chemistry · 2017Article
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Diamond nanowires: a novel platform for electrochemistry and matrix-free mass spectrometry.Sensors (Basel, Switzerland) · 2015Review
- Increased protein structural resolution from diethylpyrocarbonate-based covalent labeling and mass spectrometric detection.Journal of the American Society for Mass Spectrometry · 2012Article
- Using extracellular matrix proteomics to understand left ventricular remodeling.Circulation. Cardiovascular genetics · 2012Review
- Mass spectrometry-based quantification of myocardial protein adducts with acrolein in an in vivo model of oxidative stress.Molecular nutrition & food research · 2011Article
- Mass spectrometric methods for monitoring redox processes in electrochemical cells.Mass spectrometry reviewsReview
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Authors and funding
4 authors.
Funding
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Abstract
Oxidation of proteins and peptides is a common phenomenon, and can be employed as a labeling technique for mass-spectrometry-based proteomics. Nonspecific oxidative labeling methods can modify almost any amino acid residue in a protein or only surface-exposed regions. Specific agents may label reactive functional groups in amino acids, primarily cysteine, methionine, tyrosine, and tryptophan. Nonspecific radical intermediates (reactive oxygen, nitrogen, or halogen species) can be produced by chemical, photochemical, electrochemical, or enzymatic methods. More targeted oxidation can be achieved by chemical reagents but also by direct electrochemical oxidation, which opens the way to instrumental labeling methods. Oxidative labeling of amino acids in the context of liquid chromatography(LC)-mass spectrometry (MS) based proteomics allows for differential LC separation, improved MS ionization, and label-specific fragmentation and detection. Oxidation of proteins can create new reactive groups which are useful for secondary, more conventional derivatization reactions with, e.g., fluorescent labels. This review summarizes reactions of oxidizing agents with peptides and proteins, the corresponding methodologies and instrumentation, and the major, innovative applications of oxidative protein labeling described in selected literature from the last decade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.