ArticleOncogene2010
Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Detection and identification of cis-regulatory elements using change-point and classification algorithms.BMC genomics · 2022Article
- Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems.Biomedicines · 2021Review
- Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes.Scientific reports · 2019Article
- A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.Journal of the American Society of Nephrology : JASN · 2019Article
- Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.The Journal of physiology · 2019Article
- Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.Nature genetics · 2018Article
- Article
- Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach.Nucleic acids research · 2017Article
- PHOX2B is a suppressor of neuroblastoma metastasis.Oncotarget · 2016Article
- Article
- Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche.Frontiers in neuroscience · 2016Review
- GATA-3 augmentation down-regulates Connexin43 in Helicobacter pylori associated gastric carcinogenesis.Cancer biology & therapy · 2015Article
- Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma.Cancer cell international · 2015Article
- Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth.Breast cancer research : BCR · 2014Article
- Loss of GATA3 in bladder cancer promotes cell migration and invasion.Cancer biology & therapy · 2014Article
- The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells.PloS one · 2014Article
- Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas.PloS one · 2013Article
- LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.Nature genetics · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost all neuroblastoma tumors express excess levels of Cyclin D1 (CCND1) compared to normal tissues and other tumor types. Only a small percentage of these neuroblastoma tumors have high-level amplification of the Cyclin D1 gene. The other neuroblastoma tumors have equally high Cyclin D1 expression without amplification. Silencing of Cyclin D1 expression was previously found to trigger differentiation of neuroblastoma cells. Overexpression of Cyclin D1 is therefore one of the most frequent mechanisms with a postulated function in neuroblastoma pathogenesis. The cause for the Cyclin D1 overexpression is unknown. Here we show that Cyclin D1 overexpression results from transcriptional upregulation. To identify upstream regulators, we searched in mRNA profiles of neuroblastoma tumor series for transcription factors with expression patterns correlating to Cyclin D1. GATA3 most consistently correlated to Cyclin D1 in four independent data sets. We identified a highly conserved GATA3 binding site 27 bp upstream of the Cyclin D1 transcriptional start. Chromatin immune precipitation confirmed binding of GATA3 to the Cyclin D1 promoter. Overexpression of GATA3 induced Cyclin D1 promoter activity, which decreased after site-directed mutagenesis of the GATA3 binding site in the Cyclin D1 promoter. Silencing of GATA3 resulted in reduced Cyclin D1 promoter activity and reduced Cyclin D1 mRNA and protein levels. Moreover, GATA3 silencing caused differentiation that was similar to that caused by Cyclin D1 inhibition. These finding implicate GATA3 in Cyclin D1 overexpression in neuroblastoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.