ReviewCurrent opinion in lipidology2010
Adaptive genetic variation and heart disease risk.
Review in Current opinion in lipidology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Gene regulation underlies environmental adaptation in house mice.Genome research · 2018Article
- Perspective: Improving Nutritional Guidelines for Sustainable Health Policies: Current Status and Perspectives.Advances in nutrition (Bethesda, Md.) · 2017Article
- Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge.Journal of lipid research · 2016Article
- Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort.Genes & nutrition · 2016Article
- CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.BioData mining · 2014Article
- How Gene Networks Can Uncover Novel CVD Players.Current cardiovascular risk reports · 2014Article
- Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations.The Journal of nutrition · 2013Article
- APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population.The Journal of nutrition · 2011Article
- Decreased high-density lipoprotein cholesterol levels in polyarticular juvenile idiopathic arthritis.Clinics (Sao Paulo, Brazil) · 2011Article
- Experimental Evolution and Heart Function in Drosophila.Physiological and biochemical zoology : PBZArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewObesity, dyslipidemia and cardiovascular disease are complex and determined by both genetic and environmental factors and their inter-relationships. Many associations from genome-wide association studies and candidate gene approaches have described a multitude of polymorphisms associating with lipid and obesity phenotypes but identified genetic variants account for only a small fraction of phenotypic variation. RECENT
findingsThat many genotype-phenotype associations involve variants under positive selection and that those variants respond to environmental cues together suggest prominent roles for both genetic adaptation and their interactions with the environment. Adaptive genetic variations interacting with environment modulate disease susceptibility but the level to which those variants contribute to dyslipidemia and obesity and how environmental factors, especially diet, alter the genetic association is not yet completely known. SUMMARY: It is evident that genetic variants under positive selection make important contributions to obesity and heart disease risk. Advances in resequencing the entire human genome will enable accurate identification of adaptive variants. Considering interactions between environmental factors and genotypes will empower both genome-wide association studies and characterization of the relationship between positive selection and the obese and dyslipidemic conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.