Evidence map›Paper›PMID 20154609›Full record

ReviewCurrent opinion in clinical nutrition and metabolic care2010

Functional consequences of sarcopenia and dynapenia in the elderly.

Brian C Clark, Todd M Manini

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in clinical nutrition and metabolic care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 150 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 8 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02898701 nacompletednot on this mapstarted 2016, after this paper: background citation

Does Practice Beyond Performance Plateau Improve Motor Learning in Healthy Adults?

TypeinterventionalSponsorUniversity of UtahRan2016 to 2020Enrolled65ConditionsAgingArmsMotor Practice of a Standing Serial Reaction Time Task
NCT06621875 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effect Of The Presence Of Dynapenia On Posture, Spine Muscle Elasticity, Strength And Endurance In Young Adults

TypeobservationalSponsorAynur AyazzadeRan2024 to 2025Enrolled40ConditionsDynapenia, Muscle Weakness, Sarcopenia
NCT07253714 nacompletednot on this mapstarted 2024, after this paper: background citation

The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes

TypeinterventionalSponsorAtılım UniversityRan2024 to 2024Enrolled31ConditionsSarcopenia in ElderlyArmsClassic exercises, Proprioceptive exercise training
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 8 syntheses or guidelines pooled it, 356 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Brian C ClarkInstitute for Neuromusculoskeletal Research, Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA.
Todd M Manini
Ohio University · USUniversity of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Intracortical Mechanisms of Muscle WeaknessR15HD065552 · NICHD · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2010 to 2011
$620k
Task Specific Exercise for the Clinically DisabledR21AG031974 · NIA · UNIVERSITY OF FLORIDA · PI MANINI, TODD · 2009 to 2010
$328k
NIA NIH HHS P30 AG028740NIA NIH HHS R21 AG031974NICHD NIH HHS R15 HD065552
6 · The paper itself

Abstract

purpose of reviewThe economic burden due to the sequela of sarcopenia (muscle wasting in the elderly) are staggering and rank similarly to the costs associated with osteoporotic fractures. In this article, we discuss the societal burden and determinants of the loss of physical function with advancing age, the physiologic mechanisms underlying dynapenia (muscle weakness in the elderly), and provide perspectives on related critical issues to be addressed. RECENT

findingsRecent epidemiological findings from longitudinal aging studies suggest that dynapenia is highly associated with both mortality and physical disability even when adjusting for sarcopenia indicating that sarcopenia may be secondary to the effects of dynapenia. These findings are consistent with the physiologic underpinnings of muscle strength, as recent evidence demonstrates that alterations in muscle quantity, contractile quality and neural activation all collectively contribute to dynapenia. SUMMARY: Although muscle mass is essential for regulation of whole body metabolic balance, overall neuromuscular function seems to be a critical factor for maintaining muscle strength and physical independence in the elderly. The relative contribution of physiologic factors contributing to muscle weakness are not fully understood and further research is needed to better elucidate these mechanisms between muscle groups and across populations.

Indexed as

Activities of Daily LivingPersons with DisabilitiesAgedHumansMuscle, SkeletalMuscle WeaknessSarcopenia

Identifiers

PMID20154609
PMCPMC2895460
OpenAlexW2064516207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.