ArticleJournal of lipid research2010
Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes.Journal of lipid research · 2013Trial
- RamanOmics decodes the spatial vibrational-molecular architecture of senescence in aging and repair.Nature aging · 2026Article
- Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities.Adipocyte · 2024Review
- Effects of SGLT2 inhibition on lipid transport in adipose tissue in type 2 diabetes.Endocrine connections · 2022Article
- A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens.Environmental health perspectives · 2021Article
- Identification of contributing genes of Huntington's disease by machine learning.BMC medical genomics · 2020Article
- Article
- A Novel Proangiogenic Function of Fsp27 in Endothelium: You Only Live Thrice?Journal of the American Heart Association · 2019Article
- CIDE Proteins in Human Health and Disease.Cells · 2019Review
- Comparative Proteome Analysis Reveals Lipid Metabolism-Related Protein Networks in Response to Rump Fat Mobilization.International journal of molecular sciences · 2018Article
- Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle.Scientific reports · 2015Article
- Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes.Scientific reports · 2015Article
- Cell death-inducing DFFA-like effector c (CIDEC/Fsp27) gene: molecular cloning, sequence characterization, tissue distribution and polymorphisms in Chinese cattles.Molecular biology reports · 2013Article
- The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population.Molecular biology reports · 2013Article
- DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.Mutagenesis · 2012Article
- Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes.Journal of lipid research · 2011Article
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Authors and funding
5 authors.
Funding
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Abstract
Both insulin and the cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) family play important roles in apoptosis and lipid droplet formation. However, regulation of the CIDE family by insulin and the contribution of the CIDE family to insulin actions remain unclear. Here, we investigated whether insulin regulates expression of the CIDE family and which subtypes contribute to insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. Insulin decreased CIDEA and increased CIDEC but not CIDEB mRNA expression. Starvation-induced apoptosis in adipocytes was significantly inhibited when insulin decreased the CIDEA mRNA level. Small interfering RNA-mediated depletion of CIDEA inhibited starvation-induced apoptosis similarly to insulin and restored insulin deprivation-reduced adipocyte number, whereas CIDEC depletion did not. Lipid droplet size of adipocytes was increased when insulin increased the CIDEC mRNA level. In contrast, insulin-induced enlargement of lipid droplets was markedly abrogated by depletion of CIDEC but not CIDEA. Furthermore, depletion of CIDEC, but not CIDEA, significantly increased glycerol release from adipocytes. These results suggest that CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation.
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