ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2010
Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.American journal of respiratory and critical care medicine · 2014Trial
- Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population.International journal of molecular sciences · 2026Article
- C-Reactive Protein Controls IL-23 Production by Human Monocytes.International journal of molecular sciences · 2021Article
- Host Epigenetics in Intracellular Pathogen Infections.International journal of molecular sciences · 2020Review
- Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris.Dermatology reports · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A newly described heterodimeric cytokine, interleukin-23 (IL-23) is emerging as a key player in both the innate and the adaptive T helper (Th)17 driven immune response as well as an initiator of several autoimmune diseases. The rate-limiting element of IL-23 production is believed to be driven by expression of the unique p19 subunit encoded by IL23A. We set out to perform comprehensive DNA sequencing of this previously under-studied gene in 96 individuals from two evolutionary distinct human population groups, Southern African Bantu and European. We observed a total of 33 different DNA variants within these two groups, 22 (67%) of which are currently not reported in any available database. We further demonstrate both inter-population and intra-species sequence conservation within the coding and known regulatory regions of IL23A, supporting a critical physiological role for IL-23. We conclude that IL23A may have undergone positive selection pressure directed towards conservation, suggesting that functional genetic variants within IL23A will have a significant impact on the host immune response.
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Registered trials
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