ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration.British journal of pharmacology · 2018Review
- Studying GPCR/cAMP pharmacology from the perspective of cellular structure.Frontiers in pharmacology · 2015Review
- Role of p21-activated kinases in cardiovascular development and function.Cellular and molecular life sciences : CMLS · 2013Review
- Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1.Journal of molecular and cellular cardiology · 2013Article
- Novel roles of PAK1 in the heart.Cellular logistics · 2012Article
- Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.Journal of molecular and cellular cardiology · 2011Article
- Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.Progress in biophysics and molecular biology · 2010Review
- The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes.The Journal of general physiology · 2010Article
- The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion.Cardiovascular journal of AfricaArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
Although bradykinin (BK) is known to exert effects on the myocardium, its intracellular signaling pathways remain poorly understood. Experiments in other cell types indicated that p21-activated kinase-1 (Pak1), a Ser/Thr kinase downstream of small monomeric G proteins, is activated by BK. We previously reported that the expression of active Pak1 in adult cardiac myocytes induced activation of protein phosphatase 2A and dephosphorylation of myofilament proteins (Ke et al. Circ Res 94: 194-200, 2004). In experiments reported here, we tested the hypothesis that BK signals altered protein phosphorylation in adult rat cardiac myocytes through the activation and translocation of Pak1. Treatment of myocytes with BK resulted in the activation of Pak1 as demonstrated by increased autophosphorylation at Thr423 and a diminished striated localization, which is present in the basal state. BK induced dephosphorylation of both cardiac troponin I and phospholamban. Treatment of isolated myocytes with BK also blunted the effect of isoproterenol to enhance peak Ca(2+) and relaxation of Ca(2+) transients. Protein phosphatase 2A was demonstrated to associate with both Pak 1 and phospholamban. Our studies indicate a novel signaling mechanism for BK in adult rat cardiac myocytes and support our hypothesis that Pak 1 is a significant regulator of phosphatase activity in the heart.
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