ArticleCanadian family physician Medecin de famille canadien2010
Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy.
Article in Canadian family physician Medecin de famille canadien, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Interventions for heartburn in pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Association Between Female Reproductive Factors and Laryngopharyngeal Reflux: A National Population-Based Study.Journal of clinical medicine · 2026Article
- Review
- Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review.Medicine · 2022Review
- Anatomical and physiological alterations of pregnancy.Journal of pharmacokinetics and pharmacodynamics · 2020Review
- Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Nausea and vomiting of pregnancy - What's new?Autonomic neuroscience : basic & clinical · 2017Review
- Heartburn in pregnancy.BMJ clinical evidence · 2015Review
- Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial.Obstetrics and gynecology international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
questionIn addition to suffering from nausea and vomiting of pregnancy, which is being treated with antiemetics, some of my pregnant patients complain of heartburn and acid reflux. Should these symptoms also be treated and, if so, which acid-reducing medications are safe for use during pregnancy? ANSWER: Increased severity of nausea and vomiting of pregnancy is associated with the presence of heartburn and acid reflux. Antacids, histamine-2 receptor antagonists, and proton pump inhibitors can be used safely during pregnancy, as large studies have been published with no evidence of adverse fetal effects.
Indexed as
Identifiers
20154244PMC2821234W1946578812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.