ReviewSchizophrenia bulletin2010
The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?
Review in Schizophrenia bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response.Brain imaging and behavior · 2019Trial
- Amphetamine sensitization alters reward processing in the human striatum and amygdala.PloS one · 2014Trial
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Nature and Correlates of Executive Dysfunction in Schizophrenia: An Exploratory Study.Indian journal of psychological medicine · 2021Article
- Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli.Schizophrenia bulletin · 2020Article
- Neural Mechanisms of Strategic Adaptation in Attentional Flexibility.Journal of cognitive neuroscience · 2020Article
- The muscarinic MNeuroImage. Clinical · 2020Article
- Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder.Psychopharmacology · 2019Article
- Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study.Translational psychiatry · 2018Article
- Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Studying Delusions Within Research Domain Criteria: The Challenge of Configural Traits When Building a Mechanistic Foundation for Abnormal Beliefs.Schizophrenia bulletin · 2017Review
- Use of a Structured Mirrors Intervention Does Not Reduce Delirium Incidence But May Improve Factual Memory Encoding in Cardiac Surgical ICU Patients Aged Over 70 Years: A Pilot Time-Cluster Randomized Controlled Trial.Frontiers in aging neuroscience · 2016Article
- Computational Psychiatry: towards a mathematically informed understanding of mental illness.Journal of neurology, neurosurgery, and psychiatry · 2016Review
- Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents.Journal of affective disorders · 2016Article
- Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia.NeuroImage. Clinical · 2016Article
- Practice and Learning: Spatiotemporal Differences in Thalamo-Cortical-Cerebellar Networks Engagement across Learning Phases in Schizophrenia.Frontiers in psychiatry · 2016Article
- Poor premorbid school performance, but not severity of illness, predicts cognitive decline in schizophrenia in midlife.Schizophrenia research. Cognition · 2015Article
- Fronto-striatal dysfunction during reward processing in unaffected siblings of schizophrenia patients.Schizophrenia bulletin · 2015Article
- Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus.Neurobiology of learning and memory · 2013Article
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3 authors.
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Abstract
Associative learning experiments in schizophrenia and other psychoses reveal subtle abnormalities in patients' brain responses. These are sometimes accompanied by intact task performance. An important question arises: How can learning occur if the brain system is not functioning normally? Here, we examine a series of possible explanations for this apparent discrepancy: (1) standard brain activation patterns may be present in psychosis but partially obscured by greater noise, (2) brain signals may be more sensitive to real group differences than behavioral measures, and (3) patients may achieve comparable levels of performance to control subjects by employing alternative or compensatory neural strategies. We consider these explanations in relation to data from causal- and reward-learning imaging experiments in first-episode psychosis patients. The findings suggest that a combination of these factors may resolve the question of why performance is sometimes preserved when brain patterns are disrupted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.