ArticleChest2010
A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction.
Article in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Pooled it
- Effect of physical training on airway inflammation in bronchial asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Comparing traditional and participatory dissemination of a shared decision making intervention (ADAPT-NC): a cluster randomized trial.Implementation science : IS · 2014Trial
- The relationship of Systemic Inflammatory Index with asthma in adults: A retrospective cross-sectional study.The Journal of international medical research · 2025Article
- Association of High-Sensitivity C-Reactive Protein Levels with Proximal Airway CT Morphology in Obesity.Obesity surgery · 2025Article
- An analysis of the global burden of childhood and adolescent asthma attributable to high BMI: 1990-2021.Frontiers in pediatrics · 2025Article
- The Role of Peptides in Asthma-Obesity Phenotype.International journal of molecular sciences · 2024Review
- Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma.ERJ open research · 2022Article
- Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma?Frontiers in pediatrics · 2019Review
- Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.Respiratory medicine · 2017Article
- Physical activity, restrictions in activity, and body mass index among urban children with persistent asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.Therapeutic advances in chronic disease · 2017Review
- Costs Attributable to Overweight and Obesity in Working Asthma Patients in the United States.Yonsei medical journal · 2017Article
- Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.Mediators of inflammation · 2016Review
- Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
- Body mass index, respiratory conditions, asthma, and chronic obstructive pulmonary disease.Respiratory medicine · 2015Article
- Chronic Comorbidities Contribute to the Burden and Costs of Persistent Asthma.Mediators of inflammation · 2015Article
- Approach to Patients with Severe Asthma: a Consensus Statement from the Respiratory Care Experts' Input Forum (RC-EIF), Iran.Tanaffos · 2015Review
- Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.Environmental health perspectives · 2013Article
- Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea.The journal of allergy and clinical immunology. In practice · 2013Article
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Authors and funding
13 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveThe objectives of our study were to compare patient characteristics and severity of disease in obese and normal-weight-confirmed people with asthma and to explore reasons for misdiagnosis of asthma, including potential interactions with obesity.
methodsWe randomly selected patients with physician-diagnosed asthma from eight Canadian cities. Asthma diagnosis was confirmed via a sequential lung function testing algorithm. Logistic analysis was conducted to compare obese and normal-weight-confirmed people with asthma and to assess characteristics associated with misdiagnosis of asthma. Interaction with obesity was investigated.
resultsComplete assessments were obtained on 496 subjects who reported physician-diagnosed asthma (242 obese and 254 normal-weight subjects); 346 had asthma confirmed with sequential lung testing, and in 150 subjects a diagnosis of asthma was ruled out. Obese subjects with asthma were significantly more likely to be men, have a history of hypertension and gastroesophageal reflux disease, and have a lower FEV(1) compared with normal-weight subjects with asthma. Older subjects, men, and subjects with higher FEV(1) were more likely to have received misdiagnoses of asthma. Obesity was not an independent predictor of misdiagnosis, however there was an interaction between obesity and urgent visits for respiratory symptoms. The odds ratio for receiving a misdiagnosis of asthma for obese individuals as compared with normal-weight individuals was 4.08 (95% CI, 1.23-13.5) for those with urgent visits in the past 12 months.
conclusionsObese people with asthma have lower lung function and more comorbidities compared with normal-weight people with asthma. Obese individuals who make urgent visits for respiratory symptoms are more likely to receive a misdiagnosis of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.