ArticleEukaryotic cell2010
Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- SEA and GATOR 10 Years Later.Cells · 2021Review
- Article
- GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle.Nature chemical biology · 2017Article
- Conceptualizing Eukaryotic Metabolic Sensing and Signaling.Journal of the Indian Institute of Science · 2017Article
- Multiple Targets on the Gln3 Transcription Activator Are Cumulatively Required for Control of Its Cytoplasmic Sequestration.G3 (Bethesda, Md.) · 2016Article
- SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.Journal of cell science · 2015Review
- TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.Science signaling · 2014Article
- The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.Cell death and differentiation · 2014Article
- Changes in cell morphology are coordinated with cell growth through the TORC1 pathway.Current biology : CB · 2013Article
- Uncovering ubiquitin and ubiquitin-like signaling networks.Chemical reviews · 2011Review
- Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.Molecular biology of the cell · 2011Article
- A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.Molecular biology of the cell · 2011Article
- A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.Molecular & cellular proteomics : MCP · 2011Article
- Article
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6 authors at 1 institution in 1 country.
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Abstract
Npr2, a putative "nitrogen permease regulator" and homolog of the human tumor suppressor NPRL2, was found to interact with Grr1, the F-box component of the SCF(Grr1) (Skp1-cullin-F-box protein complex containing Grr1) E3 ubiquitin ligase, by mass spectrometry-based multidimensional protein identification technology. Npr2 has two PEST sequences and has been previously identified among ubiquitinated proteins. Like other Grr1 targets, Npr2 is a phosphoprotein. Phosphorylated Npr2 accumulates in grr1Delta mutants, and Npr2 is stabilized in cells with inactivated proteasomes. Phosphorylation and instability depend upon the type I casein kinases (CK1) Yck1 and Yck2. Overexpression of Npr2 is detrimental to cells and is lethal in grr1Delta mutants. Npr2 is required for robust growth in defined medium containing ammonium or urea as a nitrogen source but not for growth on rich medium. npr2Delta mutants also fail to efficiently complete meiosis. Together, these data indicate that Npr2 is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources.
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