Evidence map›Paper›PMID 20153900›Full record

Trial reportOphthalmology2010

Vitamin E and age-related macular degeneration in a randomized trial of women.

William G Christen, Robert J Glynn, Emily Y Chew, Julie E Buring

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

William G ChristenDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.edu
Robert J Glynn
Emily Y Chew
Julie E Buring
Brigham and Women's Hospital · USHarvard University · USNational Eye Institute · US

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASER01EY006633 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTEN, WILLIAM G · 1986 to 2002
$876k
Intramural NIH HHS Z99 EY999999NCI NIH HHS CA 47988NCI NIH HHS R01 CA047988NEI NIH HHS EY 06633NEI NIH HHS R01 EY006633NHLBI NIH HHS HL 43851NHLBI NIH HHS R01 HL043851
6 · The paper itself

Abstract

objectiveTo test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.

designRandomized, double-masked, placebo-controlled trial.

participantsThirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.

interventionParticipants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo.

main outcome measuresIncident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

resultsAfter 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19).

conclusionsIn a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.

Indexed as

Women's HealthAgedAntioxidantsBody Mass IndexDouble-Blind MethodFemaleFollow-Up StudiesHumansIncidenceMacular DegenerationMiddle AgedProportional Hazards ModelsVisual AcuityVitamin EAntioxidantsVitamin E

Identifiers

PMID20153900
PMCPMC2881167
OpenAlexW2062241029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.