ArticleBehavioural brain research2010
Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats.
Article in Behavioural brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies.The Korean journal of internal medicine · 2018Pooled it
- Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats.Fundamental & clinical pharmacology · 2026Article
- Differential regulation of KExperimental animals · 2025Article
- Pharmacotherapeutic management of insomnia and effects on sleep processes, neural plasticity, and brain systems modulating stress: A narrative review.Frontiers in neuroscience · 2022Review
- Eszopiclone and Zolpidem Produce Opposite Effects on Hippocampal Ripple Density.Frontiers in pharmacology · 2021Article
- Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.Depression and anxiety · 2020Review
- Revealing the sedative-hypnotic effect of the extracts of herb pair Semen Ziziphi spinosae and Radix Polygalae and related mechanisms through experiments and metabolomics approach.BMC complementary medicine and therapies · 2020Article
- Article
- Valium without dependence? Individual GABANeuropsychiatric disease and treatment · 2018Review
- The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The homeostatic regulation of REM sleep: A role for localized expression of brain-derived neurotrophic factor in the brainstem.Behavioural brain research · 2015Article
- Benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala.Anesthesia and analgesia · 2014Article
- The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABA(A) receptors.Psychopharmacology · 2014Review
- Dorsal subcoeruleus nucleus (SubCD) involvement in context-associated fear memory consolidation.Experimental brain research · 2014Article
- Article
- The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats.Frontiers in neuroscience · 2014Article
- Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task.Psychopharmacology · 2013Article
- About sleep's role in memory.Physiological reviews · 2013Review
- Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats.Frontiers in neurology · 2013Article
- Sharing stressful experiences attenuates anxiety-related cognitive and sleep impairments.Behavioural brain research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
At present, eszopiclone and zolpidem are the most commonly prescribed drugs for treating insomnia. Despite the established relationship between sleep disturbance and anxiety, it remains unknown whether targeted treatment for insomnia may affect acute anxiety. Therefore, the objective of this study was to examine the effects of three different doses (1, 3, and 10mg/kg) of eszopiclone and zolpidem on the states of sleep and wakefulness, levels of anxiety-like behavior, and long-term contextual memory in footshock-induced anxious rats. The results of this study demonstrated that the administration of eszopiclone and zolpidem both were equally effective in attenuating footshock stressor-induced suppression of slow-wave sleep (SWS). The administration of eszopiclone at 1mg/kg or zolpidem at 1 and 3mg/kg doses showed a tendency for attenuating stressor-induced suppression of REM sleep. However, the REM sleep attenuating effects of these drugs disappeared when they were administered at higher doses. The administration of eszopiclone at 3 and 10mg/kg doses and zolpidem at all three doses reduced the power of electroencephalographic theta band frequencies during wakefulness. In addition, the administration of eszopiclone at 1 and 3mg/kg doses suppressed stressor-induced anxiety-like behavior. The administration of zolpidem at 1, 3, or 10mg/kg doses was not effective in attenuating stressor-induced anxiety-like behavior. Contextual memory after administration of eszopiclone at 1mg/kg dose had no effects, but was reduced significantly with increased dosage. Contextual memory after administration of zolpidem, at all three doses, was severely disrupted. The results of this study suggest that eszopiclone at a low dose could be used effectively to control anxiety and anxiety-induced insomnia.
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