ArticleBiochemical and biophysical research communications2010
Daxx is reciprocally regulated by Mdm2 and Hausp.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- USP7 at PML Nuclear Bodies: A Protein Interaction Network Perspective.International journal of molecular sciences · 2026Article
- USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis.Molecules (Basel, Switzerland) · 2025Review
- The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.The Journal of biological chemistry · 2020Article
- USP7: Structure, substrate specificity, and inhibition.DNA repair · 2019Review
- Modulation of the p53/MDM2 interplay by HAUSP inhibitors.Journal of molecular cell biology · 2017Review
- Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.Cell death & disease · 2015Article
- DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.Cell cycle (Georgetown, Tex.) · 2015Article
- The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin.Molecular and cellular biology · 2014Article
- Cell death and deubiquitinases: perspectives in cancer.BioMed research international · 2014Review
- USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.Cell death and differentiation · 2013Article
- Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.Oncogenesis · 2013Article
- The Many Faces of MDM2 Binding Partners.Genes & cancer · 2012Article
- Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.Journal of virology · 2011Article
- Roles of HAUSP-mediated p53 regulation in central nervous system development.Cell death and differentiation · 2011Article
- Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases.Signal transduction and targeted therapyArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Daxx is a multifunctional protein, regulating a wide range of important functions including apoptosis and transcription. However, the way Daxx is regulated is poorly understood. In our previous studies, we have found that Daxx forms a complex with the E3 ubiquitin ligase Mdm2 and the de-ubiquitinase Hausp. In the present work, we show that Daxx is ubiquitinated by Mdm2 in both in vitro and in vivo systems and Mdm2 reduces Daxx expression upon over-expression. We further demonstrate that Hausp critically controls the cellular level of Daxx most likely by inducing Daxx de-ubiquitination. These results reveal Mdm2 and Hausp as important regulators for Daxx functions by controlling Daxx ubiquitination and stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.