ReviewCurrent opinion in genetics & development2010
New functions for an old variant: no substitute for histone H3.3.
Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed.
- Transcriptome and eQTL analysis reveal the novel molecular mechanism underlying salt tolerance in the phytochrome B mutant.Plant cell reports · 2026Article
- Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism.bioRxiv : the preprint server for biology · 2026Article
- Multifunctional histone variants in genome function.Nature reviews. Genetics · 2025Review
- Creation of true interspecies hybrids: Rescue of hybrid class with hybrid cytoplasm affecting growth and metabolism.Science advances · 2024Article
- Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in mouse embryonic stem cells.Protein science : a publication of the Protein Society · 2024Article
- Lysine-36 of Drosophila histone H3.3 supports adult longevity.G3 (Bethesda, Md.) · 2024Article
- Lysine-36 ofbioRxiv : the preprint server for biology · 2023Article
- Histone Variants and Their Chaperones in Hematological Malignancies.HemaSphere · 2023Review
- Involvement of the H3.3 Histone Variant in the Epigenetic Regulation of Gene Expression in the Nervous System, in Both Physiological and Pathological Conditions.International journal of molecular sciences · 2023Review
- Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing.Science advances · 2023Article
- A knockout-first model of H3f3a gene targeting leads to developmental lethality.Genesis (New York, N.Y. : 2000) · 2023Article
- Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of Histone H3 Gene Family Reveals ThatFrontiers in genetics · 2022Article
- Cell Biology of Giant Cell Tumour of Bone: Crosstalk between m/wt Nucleosome H3.3, Telomeres and Osteoclastogenesis.Cancers · 2021Review
- H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos.Reproductive biology and endocrinology : RB&E · 2021Article
- Review
- An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.Nature communications · 2020Article
- Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy.Nature genetics · 2020Article
- Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells.Science (New York, N.Y.) · 2020Article
- Chromatin regulation and dynamics in stem cells.Current topics in developmental biology · 2020Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast. However, recent genetic studies in flies have challenged its importance as a mark of active chromatin, and revealed unexpected insights into essential functions of H3.3 in the germline. With strikingly little amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.