Evidence map›Paper›PMID 20153622›Full record

ReviewCurrent opinion in immunology2010

Host-microbe interactions in the developing zebrafish.

Michelle Kanther, John F Rawls

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 224 citations in OpenAlex.

  1. Article
  2. Article
  3. Zebrafish (Ecology and evolution · 2024
    Article
  4. Article
  5. Zebrafish (bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. A novel gnotobiotic experimental system for Atlantic salmon (Frontiers in cellular and infection microbiology · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michelle KantherCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
John F Rawls
University of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Microbial Regulation of Host Nutrient MetabolismR01DK081426 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAWLS, JOHN F · 2008 to 2019
$3.9M
Microbial regulation of host nutrient metabolism in gnotobiotic zebrafishK01DK073695 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAWLS, JOHN F · 2006 to 2009
$510k
NIDDK NIH HHS DK073695NIDDK NIH HHS DK081426NIDDK NIH HHS K01 DK073695NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK081426NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

The amenability of the zebrafish to in vivo imaging and genetic analysis has fueled expanded use of this vertebrate model to investigate the molecular and cellular foundations of host-microbe relationships. Study of microbial encounters in zebrafish hosts has concentrated on developing embryonic and larval stages, when the advantages of the zebrafish model are maximized. A comprehensive understanding of these host-microbe interactions requires appreciation of the developmental context into which a microbe is introduced, as well as the effects of that microbial challenge on host ontogeny. In this review, we discuss how in vivo imaging and genetic analysis in zebrafish has advanced our knowledge of host-microbe interactions in the context of a developing vertebrate host. We focus on recent insights into immune cell ontogeny and function, commensal microbial relationships in the intestine, and microbial pathogenesis in zebrafish hosts.

Indexed as

Host-Pathogen InteractionsAnimalsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHumansZebrafish

Identifiers

PMID20153622
PMCPMC3030977
OpenAlexW2040813747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.