ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2010
Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Characterizing hepatitis C virus epidemiology in Egypt: systematic reviews, meta-analyses, and meta-regressions.Scientific reports · 2018Pooled it
- The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis.BMC infectious diseases · 2013Pooled it
- Article
- Hepatitis C Virus in North Africa: An Emerging Threat.TheScientificWorldJournal · 2016Review
- Hepatitis C genotype 4: The past, present, and future.World journal of hepatology · 2015Review
- Epidemiology of hepatitis C virus exposure in Egypt: Opportunities for prevention and evaluation.World journal of hepatology · 2015Article
- Preventing hepatocellular carcinoma in Egypt: results of a Pilot Health Education Intervention Study.BMC research notes · 2015Article
- Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt.Hepatology (Baltimore, Md.) · 2015Article
- The Association between Female Genital Cutting and Spousal HCV Infection in Egypt.International journal of hepatology · 2014Article
- Article
- Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus.The Journal of pediatrics · 2013Article
- Risk factors for hepatitis C virus acquisition and predictors of persistence among Egyptian children.Liver international : official journal of the International Association for the Study of the Liver · 2012Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
A prospective study in three Egyptian villages (A, B and C) having a high prevalence of hepatitis C virus (HCV) infection examined incidence of community-acquired HCV infection in children; 2852 uninfected infants were prospectively followed from birth for up to 5.5 years. Fifteen seroconverted for either HCV antibodies and/or HCV-RNA (incidence of 0.53%). Ten had both anti-HCV and HCV-RNA; four had only anti-HCV; and one had HCV-RNA in the absence of antibody. The incidence rate at all ages was 2.7/1000 person-years (PY). It was 3.8/1000 PY during infancy and 2.0/1000 PY for the 1-5-years age group. Hospitalization and low birth weight increased the risk of infection; while living in village B, the family having a higher socioeconomic status, and advanced maternal education were protective. Six of eight HCV-infected infants reported iatrogenic exposures (e.g. hospitalization, therapeutic injections, ear piercing) prior to infection whereas only 2/7 children older than 1 year reported these exposures. Having an HCV-positive mother was the only other reported risk in two of these older children. The virus cleared in six (40%) children by the end of follow-up. Health education targeting iatrogenic exposures and focusing on risk factors could reduce HCV infection in children in high-risk populations.
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Registered trials
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