ArticleJournal of neuroscience methods2010
Computational processing of optical measurements of neuronal and synaptic activity in networks.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina.Cell reports · 2023Article
- Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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- Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.Frontiers in aging neuroscience · 2022Article
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- P2X4 Receptors Mediate CaInternational journal of molecular sciences · 2021Article
- TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury.British journal of pharmacology · 2021Article
- Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.EMBO reports · 2021Article
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Neural circuits in the mouse retina support color vision in the upper visual field.Nature communications · 2020Article
- Correction of z-motion artefacts to allow population imaging of synaptic activity in behaving mice.The Journal of physiology · 2020Article
- Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.PLoS genetics · 2020Article
- The temporal structure of the inner retina at a single glance.Scientific reports · 2020Article
- Motor Behavior Selectively Inhibits Hair Cells Activated by Forward Motion in the Lateral Line of Zebrafish.Current biology : CB · 2020Article
- Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Imaging of optical reporters of neural activity across large populations of neurones is a widely used approach for investigating the function of neural circuits in slices and in vivo. Major challenges in analysing such experiments include the automatic identification of neurones and synapses, extraction of dynamic signals, and assessing the temporal and spatial relationships between active units in relation to the gross structure of the circuit. We have developed an integrated set of software tools, named SARFIA, by which these aspects of dynamic imaging experiments can be analysed semi-automatically. Key features are image-based detection of structures of interest using the Laplace operator, determining the positions of units in a layered network, clustering algorithms to classify units with similar functional responses, and a database to store, exchange and analyse results across experiments. We demonstrate the use of these tools to analyse synaptic activity in the retina of live zebrafish by multi-photon imaging of SyGCaMP2, a genetically encoded synaptically localised calcium reporter. By simultaneously recording activity across tens of bipolar cell terminals distributed throughout the IPL we made a functional map of the ON and OFF signalling channels and found that these were only partially separated. The automated detection of signals across many neurones in the retina allowed the reliable detection of small populations of neurones generating "ectopic" signals in the "ON" and "OFF" sublaminae. This software should be generally applicable for the analysis of dynamic imaging experiments across hundreds of responding units.
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Registered trials
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