ArticleDevelopmental biology2010
Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular and Developmental Signatures of Genital Size Macro-Evolution in Bugs.Molecular biology and evolution · 2022Article
- Single-Cell Atlas of theInternational journal of molecular sciences · 2022Article
- RNAi-Mediated Silencing of Pgants Shows Core 1Frontiers in physiology · 2021Article
- The Drosophila actin nucleator DAAM is essential for left-right asymmetry.PLoS genetics · 2020Article
- Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.Development (Cambridge, England) · 2020Article
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- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at theeLife · 2018Article
- Hormone-dependent control of developmental timing through regulation of chromatin accessibility.Genes & development · 2017Article
- Left-right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis.Nature communications · 2015Article
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- Article
- A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube.PLoS genetics · 2012Article
- Insights into the dynamics of hind leg development in honey bee (Apis mellifera L.) queen and worker larvae - A morphology/differential gene expression analysis.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.