Evidence map›Paper›PMID 20152231›Full record

ArticleAmerican heart journal2010

Association of statin prescription with small abdominal aortic aneurysm progression.

Craig D Ferguson, Paula Clancy, Bernard Bourke, Philip J Walker, Anthony Dear, Tim Buckenham, Paul Norman, Jonathan Golledge

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 10 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 10 syntheses or guidelines pooled it, 166 citations in OpenAlex.

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  6. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
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  10. Pharmacotherapy in Clinical Trials for Abdominal Aortic Aneurysms: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Craig D FergusonVascular Biology Unit, Department of Surgery, School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
Paula Clancy
Bernard Bourke
Philip J Walker
Anthony Dear
Tim Buckenham
Paul Norman
Jonathan Golledge
James Cook University · AUBox Hill Hospital · AUGosford Hospital · AURoyal Brisbane and Women's Hospital · AUUniversity of Otago · NZUniversity of Western Australia · AU

Funding

Osteoprotegerin and osteopontin in aortic aneurysmR01HL080010 · NHLBI · JAMES COOK UNIVERSITY OF NO QUEENSLAND · PI GOLLEDGE, JONATHAN · 2005 to 2009
$1.3M
NHLBI NIH HHS R01 HL080010
6 · The paper itself

Abstract

backgroundStatins have been suggested to reduce expansion of abdominal aortic aneurysms (AAAs) independent of lipid-lowering effects.

methodsWe assessed the association of statin treatment and serum low-density lipoprotein (LDL) concentrations with small AAA expansion. Six hundred fifty-two patients undergoing surveillance of small AAAs were entered into the study from 5 vascular centers. In a subset, fasting lipids (n = 451) and other biomarkers (n = 216) were measured. The AAA diameter was followed by ultrasound surveillance for a median of 5 years.

resultsThree hundred forty-nine (54%) of the patients were prescribed statins. Adjusting for other risk factors, statin prescription was not associated with AAA growth (odds ratio [OR] 1.23, 95% CI 0.86-1.76). Above-median AAA growth was positively associated with initial diameter (OR 1.78 per 4.35-mm-larger initial aortic diameter, 95% CI 1.49-2.14) and negatively associated with diabetes (OR 0.37, 95% CI 0.22-0.62). Above-median serum LDL concentration was not associated with AAA growth. Patients receiving statins had lower serum C-reactive protein concentrations but similar matrix metalloproteinase-9 and interleukin-6 concentrations to those not prescribed these medications.

conclusionsWe found no association between statin prescription or LDL concentration with AAA expansion. The results do not support the findings of smaller studies and suggest that statins may have no benefit in reducing AAA progression.

Indexed as

AgedAortic Aneurysm, AbdominalDisease ProgressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipoproteins, LDLMaleHydroxymethylglutaryl-CoA Reductase InhibitorsLipoproteins, LDL

Identifiers

PMID20152231
PMCPMC2874128
OpenAlexW2166404845

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.