Evidence map›Paper›PMID 20152135›Full record

ArticleCurrent biology : CB2010

Host-pathogen interactions: proline gives insect pathogens the green light.

Nick Waterfield

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nick WaterfieldDepartment of Biology and Biochemistry, The University of Bath, Claverton Down, Bath BA2 7AY, UK. bssnw@bath.ac.uk
University of Bath · GB

Funding

Biotechnology and Biological Sciences Research Council BB/C008367/1Biotechnology and Biological Sciences Research Council BB/E021328/1
6 · The paper itself

Abstract

How does a quiescent symbiont of a nematode worm know when to turn nasty? Metabolic analysis and genetic knockouts confirm that model insect pathogens can sense L-proline in insect blood. This not only serves as a wake-up call, activating secondary metabolite virulence factors, but also provides an energy source for a metabolic shift appropriate for adaptation to the host environment.

Indexed as

AnimalsHemocytesHost-Pathogen InteractionsHumansInsectaPhotorhabdusProlineVirulenceXenorhabdusProline

Identifiers

PMID20152135
OpenAlexW2013248636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.