ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Developmental biomarkers of aging in Caenorhabditis elegans.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 57 citations in OpenAlex.
- Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium.Advanced biology · 2026Article
- The Antioxidant and Antiaging Properties of Maillard Reaction Products Derived From Dipeptide Lys-Leu inFood science & nutrition · 2026Article
- Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans.Scientific reports · 2025Article
- Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities.Journal of ginseng research · 2025Article
- Caenorhabditis elegans as a Screening Platform for Anti-aging Compounds.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Improvement of Locomotion Caused byNutrients · 2023Article
- Oligosaccharides from agar extends lifespan through activation of unfolded protein response via SIR-2.1 in Caenorhabditis elegans.European journal of nutrition · 2022Article
- Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans.Communications biology · 2022Article
- Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan.Scientific reports · 2022Article
- Article
- Article
- Extracts of the Tiger Milk Mushroom (Pharmaceuticals (Basel, Switzerland) · 2021Article
- Enhanced Healthspan inFrontiers in pharmacology · 2021Article
- Neurodevelopmental Toxicity of Polystyrene Nanoplastics inACS omega · 2020Article
- Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans.PLoS computational biology · 2020Article
- Healthspan Enhancement by Olive Polyphenols inInternational journal of molecular sciences · 2020Article
- Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.Nature communications · 2020Article
- Cellular Aging Characteristics and Their Association with Age-Related Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Antiaging, Stress Resistance, and Neuroprotective Efficacies ofOxidative medicine and cellular longevity · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The developmental process of the nematode Caenorhabditis elegans is famously invariant; however, these animals have surprisingly variable lifespans, even in extremely homogenous environments. Inter-individual differences in muscle-function decline, accumulation of lipofuscin in the gut, internal growth of food bacteria, and ability to mobilize heat-shock responses all appear to be predictive of a nematode's remaining lifespan; whether these are causal, or mere correlates of individual decline and death, has yet to be determined. Moreover, few "upstream" causes of inter-individual variability have been identified. It may be the case that variability in lifespan is entirely due to stochastic damage accumulation; alternately, perhaps such variability has a developmental origin and/or genes involved in developmental canalization also act to buffer phenotypic heterogeneity later in life. We review these two hypotheses with an eye toward whether they can be experimentally differentiated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.