ArticleMolecular biology reports2011
Characterization and expression analysis of KAP7.1, KAP8.2 gene in Liaoning new-breeding cashmere goat hair follicle.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 58 citations in OpenAlex.
- Molecular characterization and functional insights of secondary hair follicles across the cashmere growth cycle.BMC genomics · 2026Article
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- The Identification of a New GeneGenes · 2025Article
- Multi-omics analysis of functional substances and expression verification in cashmere fineness.BMC genomics · 2023Article
- Effect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing.BMC genomics · 2022Article
- Effects of exogenous melatonin on expressional differences of immune-related genes in cashmere goats.Frontiers in genetics · 2022Article
- A highly polymorphic caprine keratin-associated protein gene identified and its effect on cashmere traits.Journal of animal science · 2021Article
- Selection of Cashmere Fineness Functional Genes by Translatomics.Frontiers in genetics · 2021Article
- Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris).Scientific reports · 2020Article
- m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats.Frontiers in genetics · 2019Article
- Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter.Archives animal breeding · 2019Article
- Long noncoding RNA and gene expression analysis of melatonin-exposed Liaoning cashmere goat fibroblasts indicating cashmere growth.Die Naturwissenschaften · 2018Article
- Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats.BMC genomics · 2018Article
- Article
- A Microarray-Based Analysis Reveals that a Short Photoperiod Promotes Hair Growth in the Arbas Cashmere Goat.PloS one · 2016Article
- Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development.Journal of animal science and technology · 2015Article
- Expression analysis of KAP9.2 and Hoxc13 genes during different cashmere growth stages by qRT-PCR method.Molecular biology reports · 2014Article
- The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans.SpringerPlus · 2014Article
- Characterization of Liaoning cashmere goat transcriptome: sequencing, de novo assembly, functional annotation and comparative analysis.PloS one · 2013Article
- Variation and expression of KAP9.2 gene affecting cashmere trait in goats.Molecular biology reports · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin-associated protein is one of the major structural proteins of the hair, whose content in hair has important effect on the quality of cashmere. In order to study the relationship between HGTKAP gene expression and cashmere fineness, the quantitative real-time RT-PCR (qRT-PCR) was firstly used to detect the levels of KAP7.1, KAP8.2 gene expression in the primary and secondary hair follicles; semi-quantitative RT-PCR was used to detect whether KAP7.1, KAP8.2 gene are expressed in heart, liver, spleen, lung, kidney tissues; and in situ hybridization(ISH) to detect KAP7.1 gene expression location. qRT-PCR result showed that the expression of both KAP7.1 and KAP8.2 gene in the secondary hair follicles are significantly higher than that in the primary follicles, relative quantitative analysis obtained that KAP7.1 was 2.28 times, while KAP8.2 was 2.71 times. Semi-quantitative RT-PCR results revealed that KAP 7.1 and KAP8.2 mRNA were not detected in the heart, liver, spleen, lung and kidney tissues, demonstrating that KAP7.1 and KAP8.2 were specially expressed in hair follicles, participating in hair formation. Moreover, KAP7.1 gene has a strong expression in the cortical layer, inner root sheath of the primary follicles and the cortical layer, inner root sheath and hair matrix of the secondary hair follicles by ISH analysis. Taken together, the evidence presented here indicated that in the formation of cashmere and wool, differential expression of these two genes in the primary and secondary hair follicles may have an important role in regulating the fiber diameter.
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