ArticleJournal of mathematical biology2011
Composite likelihood-based inferences on genetic data from dependent loci.
Article in Journal of mathematical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Computationally Efficient Composite Likelihood Statistics for Demographic Inference.Molecular biology and evolution · 2016Article
- PoMo: An Allele Frequency-Based Approach for Species Tree Estimation.Systematic biology · 2015Article
- Theory and applications of a deterministic approximation to the coalescent model.Theoretical population biology · 2014Article
- Approximate Likelihood Estimation of Divergence Time Range Using a Coalescent-based Model.Evolutionary bioinformatics online · 2013Article
- Inferring species trees directly from biallelic genetic markers: bypassing gene trees in a full coalescent analysis.Molecular biology and evolution · 2012Article
- Ascertainment correction for a population tree via a pruning algorithm for likelihood computation.Theoretical population biology · 2012Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The structure of dependence between neighboring genetic loci is intractable under some models that treat each locus as a single data-point. Composite likelihood-based methods present a simple approach under such models by treating the data as if they are independent. A maximum composite likelihood estimator (MCLE) is not easy to find numerically, as in most cases we do not have a way of knowing if a maximum is global. We study the local maxima of the composite likelihood (ECLE, the efficient composite likelihood estimators), which is straightforward to compute. We establish desirable properties of the ECLE and provide an estimator of the variance of MCLE and ECLE. We also modify two proper likelihood-based tests to be used with composite likelihood. We modify our methods to make them applicable to datasets where some loci are excluded.
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Registered trials
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